Author, year Age/sex Site Additional therapy Chemotherapy drug Toxicity Outcome
Sumiyoshi et al, 2017(9)
70y/f
Lung adenocarcinoma
Right lower lobe resection
CDDP 80 mg/m2 Vinorelbine 25 mg/m2
Diarrhea, ototoxicity, AKI, hepatotoxicity, myelosupression
Death
70y/m
Esophageal squamous cell carcinoma
Subtotal esophagectomy CDDP 80 mg/m2 5-FU 800 mg/m2/day
Diarrhea, ototoxicity, AKI, hepatotoxicity, myelosupression
Death
Carneiro et al 2019(10) 23y/f Oral squamous cell carcinoma Surgery and radiotherapy CDDP 40 mg/m2 Diarrhea, AKI, Death
Gilbar et al 2021(11) 42y/m Neck cutaneous squamous cell carcinoma Surgery and radiotherapy CDDP 40 mg/m2 AKI Improved
Index case
4y/f
Facial cutaneous squamous cell carcinoma
None
Paclitaxel 175 mg/m2 Carboplatin at AUC 6
Diarrhea, AKI, hepatotoxicity
Death