Case 1:
A 46-year-old male with a history of aplastic anemia and allogeneic hematopoietic stem cell transplantation complicated by chronic graft versus host disease (GVHD) resulting in multiple past squamous cell carcinomas (SCC) of the oral cavity presented with a new \souttongue lesion. In the past he has undergone multiple resections of tongue and buccal mucosa cancers with reconstructions, a left neck dissection, and adjuvant radiotherapy. His course has been complicated by a difficult airway, vocal cord paralysis, an occluded left carotid stent, and a complex neck abscess requiring long-term antibiotic prophylaxis.
A new oral tongue lesion was first identified on routine follow-up in January 2020. The patient was asymptomatic without pain, bleeding, or difficulty eating. Exam demonstrated a lesion of the right lateral tongue with thickened leukoplakia and central depression. There was mild erythema of the mucosa but no erythroplakia. The left lateral tongue had minimal leukoplakia similar to prior exams. There were no palpable cervical lymph nodes or visible lesions on flexible nasopharyngolaryngoscopy. On repeat exam a few weeks later, the patient reported new tongue tenderness, worse on the right side. The physical appearance of the lesion was unchanged other than mildly increased thickness. Given worsening symptoms, the decision was made to perform an in-office biopsy.
Biopsy of the tongue lesion revealed squamous cell carcinoma, at least in situ, and hyperkeratotic squamous mucosa with lichenoid chronic inflammation. Pathology noted that invasive cancer could not be excluded based on the biopsy specimen. We therefore planned a transoral partial glossectomy for excision of the new tongue lesion with intraoperative assessment of margins and possible split thickness skin graft.
At this point, COVID-19 had entered our institution. Although surgery was the ideal approach to the diagnosis and treatment, we decided to delay intervention for the time being given his significant immunocompromised state and the small, relatively indolent nature of a lesion that could be monitored visually with relative ease. He is currently home quarantined with care coordinated via telemedicine including weekly photographic updates of the tongue lesion (Fig. 1).