We present a framework for identifying and flagging malfunctioning antennas in large radio interferometers. Using data from 105 antennas in the Hydrogen Epoch of Reionization Array (HERA) as a case study, we outline two distinct categories of metrics designed to detect outliers along known failure modes of the array: cross-correlation metrics, based on all antenna pairs, and auto-correlation metrics, based solely on individual antennas. We define and motivate the statistical framework for all metrics used, and present tailored visualizations that aid us in clearly identifying new and existing systematics. Finally, we provide a detailed algorithm for implementing these metrics as flagging tools on real data sets.