In this study, we examine the ability of the data assimilation of global satellite-based carbon monoxide (CO) observations to constrain high-latitude boreal wildfire emissions. We compare the optimized emissions from inversions using CO measurements from the Measurement of Pollution in the Troposphere (MOPITT) and Infrared Atmospheric Sounding Interferometer (IASI). We found that both inversions yield generally consistent posterior CO emissions globally; however, distinct differences are observed for the episodic 2017 Canadian wildfires. The 3-day global coverage of MOPITT limits its ability to accurately optimize emissions, while the daily global coverage of IASI provides a moderate improvement despite its lower surface sensitivity. Through a series of observing system simulation experiments (OSSEs), we show that the temporal coverage of IASI most strongly influenced the posterior estimates, while the differences in vertical sensitivities of MOPITT and IASI have a minor contribution.