Statistical analysis
Statistical analysis was done using Stata Version 16.0. Continuous
variables, such as age, dose and BMI were presented as medians and
interquartile ranges (IQR). Qualitative variables, such as cancer stage,
performance status and co-medications were presented as numbers and
percentages. Hardy–Weinberg equilibrium of variants and genotype
distribution were tested by χ2 (p > 0.05). The association
of DIC and the variants was evaluated using Pearson Chi-Square exact
test. We also tested the association of UGT1A6 rs17863783, SLC28A3
rs7853758 and RARG rs2229774 with cardiotoxicity using logistic
regression adjusted for age at start of treatment, cumulative
anthracycline dose and BMI. Statistical significance was set at
p< 0.05.