Association between the variants and Doxorubicin Induced Cardiotoxicity
We evaluated the association between SLC28A3 rs7853758, RARG rs2229774 and UGT1A6 rs17863783 variants and DIC. No covariate had an independent significant effect on DIC from the univariable analysis (SLC28A3 rs7853758 (p= 0.408), RARG rs2229774 (p= 0.471), UGT1A6 rs17863783 (p= 0.354), age (p= 0.124), BMI (p= 0.451) and cumulative dose (p= 0.357)). Using the stepwise method approach in multivariable analysis, we further explored whether cardiotoxicity was influenced by age, BMI and genotypes. None of these covariates were significantly affecting changes in cardiotoxicity. Thus, there was no significant relationship between cardiotoxicity and genotype, age and BMI.