Genetic results
Of the 50 patients initially recruited, 47 patients were genotyped
successfully. Hardy-Weinberg equilibrium (HWE) was calculated for each
SNP and no genotype deviated from HWE (p > 0.05) (Table
S2). The cardioprotective variant SLC28A3 rs7853758 was identified in 31
(67%) patients. The cardiotoxic risk variants UGT1A6 rs17863783 and
RARG rs2229774 were present in 10 (21.2%) and 5 (10.6%) respectively.
Among the 28 patients who were followed up to 12 months, 12 (43%) of
them carried the protective variants SLC28A3 rs7853758, 1 (4%) carried
UGT1A6 rs17863783 and 2 (8%) carried RARG rs2229774. Three (11%)
patients carried both SLC28A3 rs7853758 and UGT1A6 rs17863783 while 1
(4%) carried both SLC28A3 rs7853758 and RARG rs2229774 variants. Eight
(29%) patients did not have any genetic variation. A single patient
(4%) carried all the three variants. All three patients who developed
DIC carried SLC28A3 rs785375 variant and none of them carried RARG
rs2229774 variants. One of the 3 patients carried UGT1A6 rs17863783.