Determination of the predictive value of genotyping test
Sensitivity, specificity, positive predictive value (PPV) and negative
predictive value (NPV) was calculated to determine the predictive value
of the test. The SLC28A3 rs7853758, UGT1A6 rs17863783 and RARG rs2229774
genotypes were associated with the following parameters: sensitivity of
13% and specificity of 90% in predicting cardiotoxicity (Table 2). The
PPV of the genotype test was 33.3% while the NPV of the test was
72.0%. Both PPV and NPV are influenced by the prevalence of DIC.