Association between the variants and Doxorubicin Induced
Cardiotoxicity
We evaluated the association between SLC28A3 rs7853758, RARG rs2229774
and UGT1A6 rs17863783 variants and DIC. No covariate had an independent
significant effect on DIC from the univariable analysis (SLC28A3
rs7853758 (p= 0.408), RARG rs2229774 (p= 0.471), UGT1A6 rs17863783 (p=
0.354), age (p= 0.124), BMI (p= 0.451) and cumulative dose (p= 0.357)).
Using the stepwise method approach in multivariable analysis, we further
explored whether cardiotoxicity was influenced by age, BMI and
genotypes. None of these covariates were significantly affecting changes
in cardiotoxicity. Thus, there was no significant relationship between
cardiotoxicity and genotype, age and BMI.