Figure Legends
Figure 1. Normalized Factor IX-dose curves for (A and B) rAAV2-hAAT-FIX, (C and D) scAAV2/8-LP1-hFIXco, and (E and F) SPK-9001.The power regression was conducted using data from three species in A, C, and E and using data from two preclinical species in B, D, and F. Circle, triangle, crossing, and square symbols represent normalized FIX amounts in blood circulation of mouse, dog, macaque, and human, respectively.
Figure 2. Normalized Factor VIII-dose curves for (A and B) GO-8, (C and D) SB-525, (E and F) BMN270, (G and H) DTX201, and (I and J) SPK-8011. The power regression was conducted using data from three species in A, C, E, G, and I and using data from two preclinical species in B, D, F, H, and J. Circle, triangle, crossing, and square symbols represent normalized FVIII amounts in blood circulation of mouse, dog, macaque, and human, respectively.