Study Visits
Participants will attend an initial study visit at peanut allergy diagnosis (>12 months of age) which will include parent questionnaires, allergy history, eczema assessment and a blood test. Without prior allergy testing for tree nuts, the multi-nut OFC group will undergo multi-nut OFC and the home introduction of tree nut group will receive instructions for home introduction of individual tree nuts. Blood samples will be taken at this visit to allow retrospective analysis of tree nut sensitisation prior to tree nut introduction. Any participants reacting to multi-nut OFC or to a tree nut on home introduction will return for tree nut SPT. An individual tree nut OFC will be offered for any sensitised tree nuts (>=3mm). All participants will return for follow up at 18 months of age. This visit will include parent questionnaires, allergy history, eczema assessment, SPT and a blood test. The study assessment schedule is outlined in Table 1 and a study overview in Figure 2.