Concluding remarks
Membraneless organelles are peculiar liquid-like compartments in cells.
Membraneless organelles are unique because of their multifold
metastability, including free energy, molecular interaction, molecular
structure, and materials state. What’s more, the alteration of
metastability has been tightly linked to diseases. We envision that
further elucidation of metastability in liquid phase separation,
especially in the formation, maintenance and modulation of liquid-like
MLOs, can contribute to the insight into cell physiology and mechanisms
of pathogenesis (see Outstanding Questions ).