Outstanding Questions
How can membraneless organelles attain both supersaturation and high
selectivity of a plethora of biomolecules?
Is it possible to predict phase behavior of IDPs in different
environment simply from the information of sequence?
Why do ‘upper critical solution temperature’ and ‘lower critical
solution temperature’ phase behaviors often exist with intracellular and
extracellular intrinsically disordered proteins, respectively? Is there
any biological significance or reason?
How and to what extent can cells prevent the pathological aggregation
from metastable membraneless organelles?
Is the maturation process in cells inevitable?
How to rescue the stable amyloid-like assemblies by therapeutic
intervention? Will this be an effective pathway for the treatment of
neurodegenerative diseases and cancer?