Outstanding Questions
How can membraneless organelles attain both supersaturation and high selectivity of a plethora of biomolecules?
Is it possible to predict phase behavior of IDPs in different environment simply from the information of sequence?
Why do ‘upper critical solution temperature’ and ‘lower critical solution temperature’ phase behaviors often exist with intracellular and extracellular intrinsically disordered proteins, respectively? Is there any biological significance or reason?
How and to what extent can cells prevent the pathological aggregation from metastable membraneless organelles?
Is the maturation process in cells inevitable?
How to rescue the stable amyloid-like assemblies by therapeutic intervention? Will this be an effective pathway for the treatment of neurodegenerative diseases and cancer?