3.4 Model Evaluation
The model was validated by visual predictive check (VPC). The results of
the VPC evaluation were presented in Figure 6. The 5th, 50th and 95th
percentiles of the observed concentration data at each time point were
generally contained within the respective 90% CI (shaded area, pink for
the 50th percentile and blue for 5th and 95th percentiles) of the
simulated data (Figure 5). There was a good agreement in the time course
and central tendency between distributions of observed and simulated
data, with no obvious bias. Overall, the estimated IIV adequately
described the observed variability in iberdomide and M12 concentrations.
Taken together, iberdomide and M12 concentrations were well
characterized by the final popPK model. This enabled the proper use of
the model for subsequent simulations.