2.7 Model Performance
Model evaluation was performed using visual predictive check (VPC) that
provided an evaluation of model assumptions and population parameter
estimates by comparing model predictions with observations. The ability
of the final popPK model to describe the observed concentration data was
evaluated by simulating 500 datasets having the same doses, dosing
schedules and sampling times as the original dataset and by performing
VPCs. Binning of observations around logical post dose time points of
interest was done to ensure sufficient density of observations.