2.1 Study Description
Three clinical studies were pooled together for popPK analysis,
including CC-220-CP-001(single ascending dose study in healthy subjects;
herein as CP-001; NCT01733875), CC-220-CP-002 (multiple ascending dose
study in healthy subjects; herein as CP-002; NCT02034773) and
CC-220-MM-001 studies (subjects with RRMM; NCT02773030). Study
description was presented in Table 1.
The studies were conducted in accordance with the ethical principles of
Good Clinical Practice. All subjects gave written informed consent prior
to enrollment. The studies were approved by the institutional review
boards of the participating center and were conducted according to the
Declaration of Helsinki and the ICH Guidelines for Good Clinical
Practice.