SHS (N=248) SHS (N=248) SHS (N=248) OHS (N=250) OHS (N=250) OHS (N=250)
Parameter SHS-PWLD EO-PE (N=56) SHS-PWLD LO-PE (N=97) SHS-PWLD NTN-P (N=95) p-value OHS-PWLD EO-PE (N=14) OHS-PWLD LO-PE (N=30) OHS-PWLD NTN-P (N=206) p-value
10-20 weeks gestation (W1)
GA (weeks) 17.0(15.3-18.0) 17.0(16.0-18.0) 18.0(15.0-19.0) 0.6930 17.0(15.8-18.0) 18.0(16.0-18.0) 17.0(16.0-18.0) 0.7259
SBP (mmHg) 123.0(120.0-128.8) * 117.0(108.0-125.5) * 113.0(105.0-120.0) <0.001 108.5(102.3-121.5) 119.5(108.8-122.5) 114.0(106.0-120.0) 0.1504
DBP (mmHg) 77.0(69.0-84.0) * 76.0(67.0-82.5) * 69.0(64.0-76.0) <0.001 70.5(67.0-78.0) 72.0(66.8-82.0) 70.0(66.0-78.0) 0.6262
Serum PlGF (pg/mL) 81.3(50.2-95.0) * 87.3(68.5-95.3) * 99.4(91.1-107.4) <0.001 85.6(59.2-97.3) ǂ 93.9(58.8-100.5) ǂ 100.5(90.5-109.4) <0.001
Serum VEGF-A (pg/mL) 117.8(95.8-150.9) * 121.0(92.1-170.2) * 187.3 (170.1-204.2) <0.001 120.6(90.2-147.4) ǂ 161.5(103.8-184.9) ǂ 187.5 (170.1-196.3) <0.001
Serum sEng (ng/mL) 7.0(5.8-9.3) * 5.9(4.3-8.5) * 4.1(3.2-5.1) <0.001 6.4(4.3-8.2) ǂ 5.5(3.1-8.03) ǂ 4.1(3.1-5.5) <0.001
Serum sFlt-1 (pg/mL) 897.5(624.9-1100) * 770.2(582.9-966.4) * 543.0(433.3-682.4) <0.001 794.1(553.9-945.0) ǂ 616.3(506.4-752.6) ǂ 533.9(434.0-660.9) <0.001
Serum 8-epiPGF2α (pg/mL) 600.0(499.2-667.6) * 506.8(391.9-668.7) * 371.9 (291.7-465.8) <0.001 535.8(364.9-641.2) ǂ 399.1(350.0-506.5) ǂ 360.1(297.8-451.7) <0.001
Urinary 8-OHdG (ng/mg Cr) 87.75(81.6-99.4) * 86.6(77.6-96.1) * 75.20(51.3-86.1) <0.001 87.5(79.6-88.8) ǂ 86.5(83.5-95.5) ǂ 76.50(54.4-85.5) <0.001
Serum 8-OHdG (ng/L) 88.0(81.2-96.1) * 83.3(74.8-92.8) * 73.1(48.9-82.2) <0.001 84.0(79.3-93.5) ǂ 81.6(71.4-85.9) ǂ 73.1(50.9-82.1) <0.001
Plasma TAC (µmol/L) 147.6(94.6-259.3) * 220.0(170.1-275.6) * 234.6(180.3-317.2) <0.001 220.5(196.7-282.7) ǂ 235.2(175.4-330.2) ǂ 249.2(179.0-315.3) <0.001
sFlt-1/PlGF ratio 10.1(7.7-13.4) * 9.8(6.8-13.5) * 4.4(3.5-5.9) <0.001 8.8(6.4-12.9) ǂ 8.2(5.7-10.4) ǂ 4.1(2.9-5.3) <0.001
8-epiPGF2alpha/PlGF ratio 7.4(5.6-9.4) * 6.9(4.9-9.6) * 3.4(2.7-4.5) <0.001 5.9(4.3-10.5) ǂ 5.8(3.8-6.9) ǂ 3.7(2.8-4.8) <0.001
8-OHdG/PlGF ratio 1.1(0.8-1.6) * 0.9(0.8-1.5) * 0.8(0.4-0.8) <0.001 0.9(0.8-1.1) ǂ 0.8(0.7-1.5) ǂ 0.7(0.4-0.8) <0.001
sEng/PlGF ratio 88.1(67.1-127.5) * 80.8(50.7-131.4) * 41.7(29.7-51.6) <0.001 71.9(40.2-100.8) ǂ 69.8(47.2-116.9) ǂ 41.8(30.0-54.8) <0.001
21-31 weeks gestation (W2)
GA (weeks) 27.5(26.0-28.0) 28.0(26.0-28.0) 28.0(26.0-28.0) 0.9963 27.0(25.7-28.0) 28.0(26.0-28.0) 28.0(26.0-28.0) 0.4607
SBP (mmHg) 134.5(121.5-138.3) *¥ 128.5(109.5-130.0) *‡ 119.5(106.5-122.5) <0.001 120.0(110-124) ǂ 121.0(110.3-124.0) ǂ 116(108-121) 0.1504
DBP (mmHg) 88.5(70.5-85.5) * 78(68.5-84.0) * 73(65.5-77.5) <0.001 72.0(68.5-79.5) 73.5(68.3-83.5) 72.5(67.5-79.5) 0.6262
Serum PlGF (pg/mL) 98.3(61.2-111.7) * 106.0(82.8-111.3) * 132.3(117.9-181.5) <0.001 105.3(71.7-117.7) ǂ 109.6(71.1-119.7) ǂ 146.8(120.9-183.6) <0.001
Serum VEGF-A (pg/mL) 152.6(109.1-210.0) * 157.6(111.3-215.5) * 280.3 (229.8-421.4) <0.001 189.0(126.0-226.9) ǂ 198.6(126.0-215.9) ǂ 288.3 (230.2-418.7) <0.001
Serum sEng (ng/mL) 8.6(7.2-11.1) * 7.5(5.7-10.3) * 5.5(4.6-6.6) <0.001 8.1(5.8-9.9) ǂ 7.0(4.4-9.8) ǂ 5.5(4.4-6.9) <0.001
Serum sFlt-1 (pg/mL) 1032(718.6-1265) * 885.7(670.3-1111) * 624.5(499.0-784.7) <0.001 913.2(636.9-1087) ǂ 708.7(582.3-865.5) ǂ 614.0(499.1-760.0) <0.001
Serum 8-epiPGF2α (pg/mL) 963.7(803.9-1145) * 826.8(625.2-1079) * 593.3 (465.3-743.0) <0.001 854.6(582.2-1015) ǂ 656.9(558.4-792.8) ǂ 574.4(475.0-720.5) <0.001
Urinary 8-OHdG (ng/mg Cr) 105.7(97.6-121.7) * 103.3(92.4-114.7) * 90.0(61.8-101.6) <0.001 103.0(97.8-113.2) ǂ 102.1(93.9-104.5) ǂ 90.4(64.6-99.9) <0.001
Serum 8-OHdG (ng/L) 98.6(91.0-107.6) * 94.1(85.7-104.6) * 81.9(54.8-92.1) <0.001 94.0(89.8-104.7) ǂ 91.3(79.9-97.4) ǂ 81.9(56.9-91.9) <0.001
Plasma TAC (µmol/L) 178.0(127.8-212.3) * 205.7(146.4-253.0) * 258.1(196.4-348.9) <0.001 189.5(142.6-239.6) ǂ 210.6(177.1-230.1) ǂ 274.1(196.9-346.8) <0.001
sFlt-1/PlGF ratio 10.8(8.3-13.9) * 10.3(7.2-14.2) * 5.5(4.19-6.9) <0.001 9.0(6.7-13.5) ǂ 8.6(6.0-10.2) ǂ 4.9(3.9-6.7) <0.001
8-epiPGF2alpha/PlGF ratio 9.7(7.5-12.2) * 9.1(6.4-13.6) * 3.9(2.8-5.0) <0.001 8.3(5.8-13.8) ǂ 7.5(5.1-9.7) ǂ 4.1(3.2-5.6) <0.001
8-OHdG/PlGF ratio 1.0(0.7-1.4) * 0.9(0.7-1.4) * 0.5(0.4-0.7) <0.001 0.8(1.2-2.2) ǂ 0.7(0.6-1.0) ǂ 0.5(0.3-0.7) <0.001
sEng/PlGF ratio 89.6(70.2-124.0) * 89.2(57.1-133.7) * 37.1(27.5-51.9) <0.001 80.7(45.2-112.4) ǂ 75.9(56.6-120.7) ǂ 41.4(28.2-53.1) <0.001