Figure 3: The area under the ROC curves for the single
biomarkers of OS and AGMs, and their combinations at early pregnancy
[W1] and mid-pregnancy [W2] for the prediction of SHS-PWLD EO-PE
(Figure 3a-c) and LO-PE (Figure 3d-f)
Overall, the mid-pregnancy (W2) 8-OHdG/PIGF ratio was the best
prognostic marker for both EO-PE (Table S4) and LO-PE(Table S5) compared to the single markers. At a cut-off value
≥9.0 for the 8-OHdG/PIGF ratio, OHS pregnant women were at 5.6-fold
increased odds [aOR =5.6, 95%CI (1.5-11.9),p <0.001] of developing EO-PE with a significantly
higher discriminating power or AUC of 0.94 (p <0.001)