(Figure 4c).
Similarly, at a cut-off value ≥ 0.80 for the 8-OHdG/PIGF ratio a significantly higher discriminating power or AUC of 0.94 (p <0.0001) (Figure 4f) , 83.3% sensitivity, 90.0% specificity were observed for predicting OHS pregnant women who developed LO-PE. At the cut-off value generated for predicting OHS who are likely to develop LO-PE, OHS-PW were at 5.1-fold increased odds (aOR=5.1, 95%CI (1.5-13.3), p <0.001) (Table S5).
Except for W1 TAC levels, all the individual and combined biomarkers of OS and AGMs yielded a significant (all p <0.05) discriminating power and adjusted odds ratios for predicting OHS pregnant women likely to develop EO-PE and LO-PE, however, the combined biomarkers yielded a highest predictive accuracy