SHS (N=248) SHS (N=248) SHS (N=248) OHS (N=250) OHS (N=250) OHS (N=250)
Parameter SHS-PWD EO-PE (N=56) SHS-PWD LO-PE (N=97) SHS-PWD NTN-PW (N=95) p-value OHS-PWD EO-PE (N=14) OHS-PWD LO-PE (N=30) OHS-PWD NTN-PW (N=206) p-value
Nulliparous 38(67.9) * 24(24.7) * 26(27.4) † <0.0001 9(64.3) ǂ 8(26.7) ǂ 3(1.5) <0.001
Family history of HTN 14(25.0) *¥ 18(18.6) *‡ 8(12.6) † 0.0197 6(42.9) ǂ 9(30.0) ǂ 4(1.9) <0.001
History of miscarriage 18(32.1) * 12(12.3) * 3(3.2) † <0.001 3(21.4) ǂ 6(20.0) ǂ 2(0.9) <0.001
Previous caesarean section 22(39.2) * 15(15.5) * 8(8.4) † <0.001 5(35.7) ǂ 3(10.0) ǂ 5(2.4) <0.001
Preterm delivery 39(69.6) * 20(20.6) *‡ 5(5.3) † <0.001 8(57.1) ǂ 15(50.0) ǂ 8(3.9) <0.001
Low monthly income 27(48.2) * 13(13.4) * 6(6.3) † <0.001 7(50.0) ǂ 5(16.7) ǂ 28(13.6) 0.0015
Maternal age (years) 34.0(21.8-38.8) * ¥ 28(24-33) * 30.0(27.0-34.0) <0.001 29.0(26.0-33.0) 28.5(22-33.5) 30.0(26.0-34.0) 0.0731
SBP (mmHg) 180.0(168-189.0) * 160.0(156.0-180.0) *‡ 120.0(114.0-122.0) † <0.001 164.0(160.0-184.0) ǂ 148.0(159.0-173.0) ǂ 116.0(114.0-121.0) <0.001
DBP (mmHg) 105.0(100-113.0) * 104.0(100.0-110.0) * 78.0(70.0-80.0) <0.001 103.0(100.0-113.0) ǂ 101.0(100.0-110.0) ǂ 76.0(69.0-80.0) <0.001
GA at delivery 32.0(32.0-33.0) * 37.0(35.0-38.0) * 38.0(37.0-39.0) <0.001 33.0(32.8-33) ǂ 36.0(34.0-37.0) ǂ 38.0(37.0-39.0) <0.001
Serum PlGF (pg/ml) 71.5(45.2-95.2) * 73.8(42.4-95.6) * 104.6(97.5-109.9) <0.001 90.1(62.2-102) ǂ 83.3(51.4-96.9) ǂ 103.5(96.8-110.1) <0.001
Serum VEGF-A (pg/ml) 114.1(71.2-137.1) 110.8(82.4-172.2) * 200.6 (182-212) <0.001 143.1(93.0-186.1) ǂ 126.7(110.5-189.2) ǂ 203.4 (182.0-232.0) <0.001
Serum sEng (ng/mL) 11.9(10.5-14.3) * 10.7(8.9-13.5) * 8.7(7.8-9.9) <0.001 11.3(9.0-13.9) ǂ 10.1(7.7-12.9) ǂ 8.5(7.6-10.2) <0.001
Serum sFlt-1 (pg/ml) 1290(898.1-1581) * 1107(837-1389) * 787.5(623.9-980) <0.001 1142(796-1358) ǂ 886(727-1082) ǂ 761.1(623-950) <0.001
Serum 8-epiPGF2α (pg/ml) 2560(2057-3115) * 2187(1599-2882) * 1472 (1185-1894) <0.001 2223(1489-2636) ǂ 1625(1428-675.8) ǂ 1466(1215-1839) <0.001
Urinary 8-OHdG (ng/mg Cr) 281.1(249.5-312.3) * 259.3(235.7-296.2) * 178.4(127.4-251.9) <0.001 258.7(251.1-303.4) ǂ 255.3(234.8-261.2) ǂ 176.5(135.1-238.8) <0.001
Serum 8-OHdG (ng/L) 142.6(131.6-155.7) * 136.1(124.0-151.2) * 118.4(79.2-133.2) <0.001 136.4(132.2-151.4) ǂ 132.1(115.6-141.9) ǂ 114.5(82.3-132.0) <0.001
Plasma TAC (µmol/l) 131.4(109.9-192.3) * 180.9(119.9-249.5) * 373.8(268.5-472.9) <0.001 160.9(112.4-225.2) ǂ 199.6(118.8-243.4) ǂ 351.6(261.9-475.8) <0.001
sFlt-1: PlGF ratio 17.5(11.8-31.1) * 15.0(11.0-23.5) * 7.4(5.7-9.5) <0.001 11.9(8.2-14.0) ǂ 12.9(9.5-18.3) ǂ 6.7(5.4-9.3) <0.001
8-epiPGF2alpha: PlGF ratio 34.4(26.1-64.8) * 29.5(20.8-48.6) * 14.7(11.3-18.7) <0.001 21.8(15.0-26.7) ǂ 24.7(15.6-35.8) ǂ 13.4(10.4-17.8) <0.001
8-OHdG: PlGF ratio 1.9(1.4-3.5) * 1.5(1.2-2.9) * 1.2(0.7-1.3) <0.001 1.5(1.2-2.2) ǂ 1.3(0.8-1.3) ǂ 1.1(0.7-1.3) <0.001
sEng: PlGF ratio 173.2(130.8-287.3) * 150.5(109.2-257.1) * 84.6(72.6-101.6) <0.001 127.8(104.0-173.2) ǂ 126.4(84.5-181.7) ǂ 84.1(72.6-100.8) <0.001