Conclusions
The incidence of PE was high among SHS compared to OHS pregnant women.
There is an imbalance in biomarkers of OS as well as AGMs at both early
2nd trimester and mid-pregnancy among SHS rather than
OHS NTN-PW who later developed PE. The single biomarkers of OS and AGMs
yielded fair discriminating power or prognostic accuracies, but their
combined biomarkers perform better as a prognostic marker for PE. The
combination of biomarkers of OS and AGMs, particularly the mid-pregnancy
8-OHdG/PlGF ratio is the best marker for predicting PE and its subtypes.
The combination of biomarkers of OS and AGMs will
increase our knowledge of the new
prognostic markers and inform clinicians of the need for a combined
antioxidant plus pro-angiogenic supplementation for women who develop
PE. The concept of SHS allows early stratification and intervention for
NTN-PW, who are at high risk of developing PE. Thus, it should be
recommended as an additional health assessment tool for antenatal care
in resource-limited communities.