Adverse drug reaction |
Achiral |
Achiral |
Chiral mixture |
Chiral mixture |
Pure
enantiomer |
Pure enantiomer |
Total |
Total |
p-value |
|
n |
% |
n |
% |
n |
% |
n |
% |
|
Hepatotoxicity |
52 |
17.0 |
21 |
12.7 |
6 |
5.4 |
79 |
13.6 |
0.008* |
No hepatotoxicity |
254 |
83.0 |
144 |
87.3 |
106 |
94.6 |
504 |
86.4 |
|
Cardiovascular |
23 |
7.5 |
24 |
14.5 |
13 |
11.6 |
60 |
10.3 |
0.049† |
Non-cardiovascular |
283 |
92.5 |
141 |
85.5 |
99 |
88.4 |
523 |
89.7 |
|
Drug abuse |
16 |
5.2 |
22 |
13.3 |
13 |
11.6 |
51 |
8.7 |
0.006‡ |
No drug abuse |
290 |
94.8 |
143 |
86.7 |
99 |
88.4 |
532 |
91.3 |
|
Neurological |
27 |
8.8 |
11 |
6.7 |
12 |
10.7 |
50 |
8.6 |
0.486 |
Non-neurological |
279 |
91.2 |
154 |
93.3 |
100 |
89.3 |
533 |
91.4 |
|
Haematological |
30 |
9.8 |
8 |
4.8 |
11 |
9.8 |
49 |
8.4 |
0.151 |
Non-haematological |
276 |
90.2 |
157 |
95.2 |
101 |
90.2 |
534 |
91.6 |
|
Carcinogenicity |
28 |
9.2 |
7 |
4.2 |
9 |
8.0 |
44 |
7.5 |
0.154 |
No carcinogenicity |
278 |
90.8 |
158 |
95.8 |
103 |
92.0 |
539 |
92.5 |
|
Dermatological |
27 |
8.8 |
9 |
5.5 |
2 |
1.8 |
38 |
6.5 |
0.029δ |
Non-dermatological |
279 |
91.2 |
156 |
94.5 |
110 |
98.2 |
545 |
93.5 |
|
Immunological |
15 |
4.9 |
8 |
4.8 |
7 |
6.2 |
30 |
5.1 |
0.841 |
Non-immunological |
291 |
95.1 |
157 |
95.2 |
105 |
93.8 |
553 |
94.9 |
|
Total |
306 |
100.0 |
165 |
100.0 |
112 |
100.0 |
583 |
100 |
|