Adverse drug reactions (n≥30) Achiral Achiral Chiral mixture Chiral mixture Pure enantiomer Pure enantiomer Total Total p-value
Mean ± SD Mean ± SD Mean ± SD Mean ± SD
Hepatotoxicity (n=79), yrs. 19.1 ± 25.8 13.8 ± 12.7 12.3 ± 19.6 17.2 ± 22.6 0.550
Cardiovascular (n=60), yrs. 17.7 ± 27.4 23.2 ± 14.4 35.9 ± 31.6 23.8 ± 24.7 0.034*
Drug abuse (n=51), yrs. 31.9 ± 33.0 31.5 ± 16.7 45.1 ± 36.0 35.1 ± 28.1 0.162
Neurological (n=50), yrs. 28.9 ± 27.6 18.8 ± 18.6 53.3 ± 62.3 32.5 ± 38.8 0.234
Haematological (n=49), yrs. 38.4 ± 31.5 16.1 ± 13.3 20.0 ± 18.6 30.7 ± 28.2 0.061
Carcinogenicity (n=44), yrs. 39.2 ± 40.5 17.9 ± 21.4 11.7 ± 6.3 30.2 ± 38.6 0.093
Dermatological (n=38), yrs. 28.4 ± 20.4 9.3 ± 10.9 18.0 ± 14.1 23.4 ± 19.8 0.018
Immunological (n=30), yrs. 38.1 ± 29.4 15.1 ± 13.9 21.3 ± 15.9 28.0 ± 25.0 0.075