Adverse drug reaction Achiral Achiral Chiral mixture Chiral mixture Pure enantiomer Pure enantiomer Total Total p-value
n % n % n % n %
Hepatotoxicity 52 17.0 21 12.7 6 5.4 79 13.6 0.008*
No hepatotoxicity 254 83.0 144 87.3 106 94.6 504 86.4
Cardiovascular 23 7.5 24 14.5 13 11.6 60 10.3 0.049
Non-cardiovascular 283 92.5 141 85.5 99 88.4 523 89.7
Drug abuse 16 5.2 22 13.3 13 11.6 51 8.7 0.006
No drug abuse 290 94.8 143 86.7 99 88.4 532 91.3
Neurological 27 8.8 11 6.7 12 10.7 50 8.6 0.486
Non-neurological 279 91.2 154 93.3 100 89.3 533 91.4
Haematological 30 9.8 8 4.8 11 9.8 49 8.4 0.151
Non-haematological 276 90.2 157 95.2 101 90.2 534 91.6
Carcinogenicity 28 9.2 7 4.2 9 8.0 44 7.5 0.154
No carcinogenicity 278 90.8 158 95.8 103 92.0 539 92.5
Dermatological 27 8.8 9 5.5 2 1.8 38 6.5 0.029δ
Non-dermatological 279 91.2 156 94.5 110 98.2 545 93.5
Immunological 15 4.9 8 4.8 7 6.2 30 5.1 0.841
Non-immunological 291 95.1 157 95.2 105 93.8 553 94.9
Total 306 100.0 165 100.0 112 100.0 583 100