Legend: LP, lumbar puncture; RP, research purposes; CC, clinical conditions; CNS, central nervous system; NCI, neurocognitive impairment; CSF, cerebrospinal fluid; ART, antiretroviral regimen; PI, protease inhibitors; NRTIs, nucleos(t)ide reverse transcriptase inhibitors; NNRTIs, non nucleos(t)ide reverse transcriptase inhibitors; INSTI, integrase strand transfer inhibitors; ARVs, antiretroviral drugs; HGRT, historical cumulative genotype resistance test; RAMs, resistance associated mutations; RT, reverse transcriptase gene; CPE, Central nervous system penetration effectiveness score.