Cases of CVE not associated with HGRT-related functional or atypical mono/dual therapy
Twenty cases (39.2%) of CVE were not associated with HGRT-related functional or atypical mono/dual therapy, so we sought to assess in which features they differ from the other CVE. No statistical differences in demographic, ART- and HIV-related characteristics were found (n=20 vs 31; Suppl.Tab.4). Overall, these 20 participants started the last ART regimen within a year in 70% of cases (versus 41.9%), despite similar overall duration on any ART; they had higher proportion of plasma suppression (75.0% versus 64.5%), lower CSF VL, and lower CD4 count, suggesting that at least part of them could have been CSF slow suppressor after viral failure requiring ART change. Thirteen participants had no GRT testing in CSF at LP, and we cannot rule out potential CSF RAMs explaining CVE. The remaining seven (13.7%) cases of CVE without plasma and CSF RAMs affecting ART are described in Suppl.Tab.5. Among these, three could be alternatively explained as CSF blip or CSF slow suppression, and four cases (7.8% of the CVE cases) remained etiologically elusive.