Time point Bedaquiline (n=13) Bedaquiline (n=13) Bedaquiline (n=13) Bedaquiline (n=13) Metabolite, M2 (n=6) Metabolite, M2 (n=6) Metabolite, M2 (n=6) Metabolite, M2 (n=6) Metabolite, M2 (n=6)
Antepartum Antepartum Postpartum Postpartum Antepartum Antepartum Antepartum Postpartum Postpartum
Time No. Concentration (mg/L) No. Concentration (mg/L) Concentration (mg/L) No. Concentration (mg/L) No. Concentration (mg/L)
Predose 6 0.419 (0.184 – 0.711) 2 0.186 (0.161 – 0.212) 0.186 (0.161 – 0.212) 6 0.183 (0.0922 – 0.218 2 0.0584 (0.0512- 0.0656)
2 hrs 6 0.621 (0.288 – 1.12) 2 0.237 (0.221 – 0.252) 0.237 (0.221 – 0.252) 6 0.160 (0.115 – 0.231) 2 0.0630 (0.0527 – 0.0732)
4 hrs 5 1.05 (0.863 – 1.32) 1 1.06 1.06 5 0.144 (0.124 – 0.204) 1 0.0467
6 hrs 5 1.69 (1.59 – 2.24) 1 1.14 1.14 5 0.181 (0.123 – 0.206) 1 0.0547
24 hrs
7
0.308 (0.287 – 0.458)
4
0.3085 (0.298 – 0.312)
0.3085 (0.298 – 0.312)
7
0.168 (0.148 – 0.458)
4
0.128 (0.117-0.142)
26 hrs
7
0.250 (0.245 – 0.443)
4
0.281 (0.269-0.286)
0.281 (0.269-0.286)
7
0.142 (0.132 – 0.241)
4
0.107 (0.105-0.112)
28 hrs
7
0.228 (0.225 – 0.391)
4
0.275 (0.269-0.283)
0.275 (0.269-0.283)
7
0.145 (0.138 - 0.226)
4
0.112 (0.109-0.119)
30 hrs 7 0.205 (0.182- 0.329) 3 0.284 (0.259-0.292) 0.284 (0.259-0.292) 7 0.133 (0.118 – 0.205) 3 0.111 (0.104-0.116)