No.: Number of participants at each timepoint

Figure 1

Visual predictive check (VPC) of the bedaquiline and M2, the top panels represent the parent, and the bottom panels represent the metabolite bedaquiline concentrations. The first column displays antepartum concentrations, while the last and middle columns shows postpartum concentration and antepartum concentration in participants co-administered lopinavir/ritonavir, respectively. Due to the small sample size in each panel, we plotted the 50^thpercentiles of the observations (red line) - the shaded areas represent the 95% model-predicted confidence intervals, and the black line is the median of the model predicted confidence interval.

Figure 2:

Pharmacokinetic profiles of bedaquiline concentrations stratified by participant ID. The red dots and purple crosses represent maternal plasma concentrations ante- and postpartum, respectively. The green triangles represent human milk; the blue squares represent infant plasma concentrations.

Figure 3:

Pharmacokinetic profiles of M2 concentrations stratified by participant ID. The red dots and purple crosses represent maternal plasma concentrations ante- and postpartum, respectively. The green triangles represent human milk; the blue squares represent infant plasma concentrations.