Time point |
Bedaquiline (n=13) |
Bedaquiline (n=13) |
Bedaquiline
(n=13) |
Bedaquiline (n=13) |
Metabolite, M2 (n=6) |
Metabolite, M2
(n=6) |
Metabolite, M2 (n=6) |
Metabolite, M2 (n=6) |
Metabolite, M2
(n=6) |
|
Antepartum |
Antepartum |
Postpartum |
Postpartum |
Antepartum |
Antepartum |
Antepartum |
Postpartum |
Postpartum |
Time |
No. |
Concentration (mg/L) |
No. |
Concentration (mg/L) |
Concentration (mg/L) |
No. |
Concentration (mg/L) |
No. |
Concentration
(mg/L) |
Predose |
6 |
0.419 (0.184 – 0.711) |
2 |
0.186 (0.161 – 0.212) |
0.186 (0.161 – 0.212) |
6 |
0.183 (0.0922 – 0.218 |
2 |
0.0584
(0.0512- 0.0656) |
2 hrs |
6 |
0.621 (0.288 – 1.12) |
2 |
0.237 (0.221 – 0.252) |
0.237
(0.221 – 0.252) |
6 |
0.160 (0.115 – 0.231) |
2 |
0.0630 (0.0527 –
0.0732) |
4 hrs |
5 |
1.05 (0.863 – 1.32) |
1 |
1.06 |
1.06 |
5 |
0.144 (0.124 –
0.204) |
1 |
0.0467 |
6 hrs |
5 |
1.69 (1.59 – 2.24) |
1 |
1.14 |
1.14 |
5 |
0.181 (0.123 –
0.206) |
1 |
0.0547 |
24 hrs
|
7
|
0.308 (0.287 –
0.458)
|
4
|
0.3085 (0.298 – 0.312)
|
0.3085 (0.298 – 0.312)
|
7
|
0.168 (0.148 – 0.458)
|
4
|
0.128 (0.117-0.142)
|
26 hrs
|
7
|
0.250 (0.245 –
0.443)
|
4
|
0.281 (0.269-0.286)
|
0.281 (0.269-0.286)
|
7
|
0.142 (0.132 – 0.241)
|
4
|
0.107 (0.105-0.112)
|
28 hrs
|
7
|
0.228 (0.225 –
0.391)
|
4
|
0.275 (0.269-0.283)
|
0.275 (0.269-0.283)
|
7
|
0.145 (0.138 - 0.226)
|
4
|
0.112 (0.109-0.119)
|
30 hrs |
7 |
0.205 (0.182- 0.329) |
3 |
0.284 (0.259-0.292) |
0.284
(0.259-0.292) |
7 |
0.133 (0.118 – 0.205) |
3 |
0.111
(0.104-0.116) |