No.: Number of participants at each timepoint
Figure 1
Visual predictive check (VPC) of the bedaquiline and M2, the top panels
represent the parent, and the bottom panels represent the metabolite
bedaquiline concentrations. The first column displays antepartum
concentrations, while the last and middle columns shows postpartum
concentration and antepartum concentration in participants
co-administered lopinavir/ritonavir, respectively. Due to the small
sample size in each panel, we plotted the 50thpercentiles of the observations (red line) - the shaded areas represent
the 95% model-predicted confidence intervals, and the black line is the
median of the model predicted confidence interval.
Figure 2:
Pharmacokinetic profiles of bedaquiline concentrations stratified by
participant ID. The red dots and purple crosses represent maternal
plasma concentrations ante- and postpartum, respectively. The green
triangles represent human milk; the blue squares represent infant plasma
concentrations.
Figure 3:
Pharmacokinetic profiles of M2 concentrations stratified by participant
ID. The red dots and purple crosses represent maternal plasma
concentrations ante- and postpartum, respectively. The green triangles
represent human milk; the blue squares represent infant plasma
concentrations.