INTRODUCTION
As we all known, cardiovascular disease (CVD) is still a leading cause
of death in the globe. Currently, it is more and more common due to
aging and unhealthy lifestyle. With the rapid development of biomedical
technology, novel diagnostic and research tools, new insights into
mechanisms and therapeutic agents, and fresh evaluation and preventive
methods (e.g., a magic “polypills”, that is,
“environment-sleep-emotion-exercise-diet” intervention
[E(e)SEEDi]) (1) make a big change in its mortality and outcomes.
As a front-line clinical doctor, the author has made giant efforts to
trace the origin and mechanisms of future CVD (fCVD). Luckily, five core
elements, “environment-sleep-emotion-exercise-diet” [E(e)SEED],
have been discovered and highly contribute to human cardiovascular
health. Based on this discovery, a novel classification of clinical risk
factors based on unhealthy E(e)SEED intervention [E(e)SEEDi]
lifestyle has been developed. In fact, many major risk factors related
to unhealthy E(e)SEEDi lifestyle could result in fCVD.
For example, as one’s internal environment, on the one hand, a genetic
or family history is an important risk factor of fCVD; On the other
hand, as major non-communicable diseases, both established CVD (eCVD)
and fCVD highly link to acute or chronic infection, which leads to
abnormal status in one’s internal environment. So far, the COVID-19
pandemics are still continuing due to the Omicron variant of SARS-CoV-2.
A recent study found that COVID-19 is a high risk factor of adverse
cardiovascular outcomes (2). It can be said that SARS-CoV-2 and its
variants are new origins of both eCVD and fCVD since there are more than
522.783 million confirmed cases and over 6.27 million deaths in the
globe (May 23, 2022) according to the report of the World Health
Organization.