The “brain-heart-gut” axis and novel mechanisms of future
cardiovascular disease (fCVD).
The new origins and novel mechanisms of fCVD link to the
“brain-heart-gut” axis disrupted by early unhealthy E(e)SEEDi
lifestyle, which is like a “Golden Hoop Curse”. In the
“brain-heart-gut” axis, the brain is the decision system, the heart is
the power system, the gut is the execution system. The three closely
cooperate and interact with each other to form the new mechanisms of
fCVD. Here, E: environment (external); e: environment (internal); S:
sleep; Em: emotion; Ex: exercise; D: diet. E(e)SEEDi:
“environment-sleep-emotion-exercise-diet” intervention. Green :
positive biofeedback by healthy E(e)SEEDi lifestyle; Grey : negative
disruption by unhealthy E(e)SEEDi lifestyle.