One of the primary aims of the DOME is to provide an accessible platform for optical interacting with microscale agents. While comparative systems have been proposed previously, none provide a fully integrated device and most provide little to no documentation to aid reproducibility. The DOME is truly open source in nature, with the STL files required to fabricate the device available online along with protocols detailing the computational set up. In addition, a video tutorial showing the step by step construction process is available (Figure 25).