MME supports connections to knowledge and model organism
resources
MME connects to three databases that provide additional utility to the
gene discovery scientific community and these databases are considered
“Connected Knowledge Sources,” or “Functional Study Node”,
specialized MME endpoints that go beyond the initial MME design of
patient-patient matchmaking (Figure 2 ). PubCaseFinder helps
users identify any existing case reports for candidate genes by using
phenotype-based comparisons (PRODUCTION: REFERENCE APPEARS IN THE SAME
SPECIAL ISSUE (Fujiwara et al., 2022, 2018) ). To facilitate
important downstream translational research using in vitro and in vivo
models (Boycott et al., 2020; Wangler et al., 2017) , MME connects
to two additional databases; Monarch Initiative and ModelMatcher. The
Monarch Initiative (Shefchek et al., 2019) , supports
patient-disease model matches (Mungall et al., 2015) , by
effectively matching patient phenotype profiles with a potentially
existing relevant disease model. ModelMatcher (PRODUCTION: REFERENCE
APPEARS IN THE SAME SPECIAL ISSUE (Harnish et al., 2022) )
facilitates cross-disciplinary collaborations as part of a global effort
to decrease the time to translational and therapeutic research by
connecting scientists and other stakeholders who have interest in the
same or orthologous gene (Neff, 2021) .