Conclusion
The time has come to use a higher dose of NAC in patients presenting
with high-dose overdose, over 500mg/kg body weight, or with evidence of
developing hepatic damage while a standard 12 h does of NAC is being
used. The animal and human data show that the earlier NAC is used the
better the outcome, and it would be illogical not to assume the same in
larger paracetamol overdose, further justifying an earlier
intensification of NAC and supporting early assessment of response that
is facilitated by the shorter SNAP NAC regimen.8