Key message
Solid food protein-induced enterocolitis syndrome (FPIES) often develops 5–12 months after birth and may be misdiagnosed as various infectious diseases that are common during that period. So far, there have been no biomarkers for FPIES, although this study shows a clear increase in certain serologic markers, particularly thymus and activation-regulated chemokine (TARC) levels, especially 24 h post-ingestion of antigen. This indicates that TARC levels may be of use for the diagnosis of FPIES, although further research is still needed.
References
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2. Nowak-Węgrzyn A, Chehade M, Groetch ME, et al. International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol 2017;139:1111-1126.e4.
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8. Hijnen D, De Bruin-Weller M, Oosting B, et al. Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis. J Allergy Clin Immunol 2004;113:334-340
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Table 1. Details of FPIES episodes