Introduction
Sepsis is a pathophysiological syndrome characterised by an overwhelming inflammatory and immune response to a bacterial, viral or fungal infection that can lead to multi-organ dysfunction and death (Singer et al., 2016). Sepsis is the leading cause of mortality in intensive care units with an annual global incidence of 49 million cases and 11 million deaths (Rudd et al., 2020). Standard of care treatment for sepsis consists of antibiotics, fluid resuscitation and vasopressors (Rhodes et al., 2017), with continuous renal replacement therapy being increasingly used in critically ill patients (Bellomo, Baldwin, Ronco & Kellum, 2021). These interventions are mostly aimed towards keeping the patient alive in the expectation that organ function should recover following resolution of the infection. However, patients who recover from severe sepsis frequently exhibit a degree of chronic organ dysfunction. Currently there are no treatments that reverse sepsis-induce organ dysfunction.