Introduction
Sickle hepatopathy of childhood encompasses a group of disorders ranging in severity from mild liver pain to multi-organ failure (Table 1).1-6 These diverse clinical manifestations are thought to reflect varying degrees of erythrocyte sickling, Kupffer cell hyperplasia, sinusoidal obstruction, hepatocyte ischemia, and intracanalicular cholestasis.2, 5, 7 Sickle hepatopathy can arise spontaneously or may be triggered by infection or autoimmune diseases.1, 5, 8, 9 Here, we describe two cases of acute sickle cell hepatopathy caused by Epstein-Barr virus (EBV), a novel association.