Introduction
Sickle hepatopathy of childhood encompasses a group of disorders ranging
in severity from mild liver pain to multi-organ failure (Table
1).1-6 These diverse clinical manifestations are
thought to reflect varying degrees of erythrocyte sickling, Kupffer cell
hyperplasia, sinusoidal obstruction, hepatocyte ischemia, and
intracanalicular cholestasis.2, 5, 7 Sickle
hepatopathy can arise spontaneously or may be triggered by infection or
autoimmune diseases.1, 5, 8, 9 Here, we describe two
cases of acute sickle cell hepatopathy caused by Epstein-Barr virus
(EBV), a novel association.