Figure Legend
Figure 1 . Acute itch flares in AD patients are associated with
increased levels of specific IgE (top left side). While chronic itch
behavior is dependent on MC-neuronal communication, acute itch relies on
basophil-neuronal interaction via the LTC4-CysLTR2 pathway (bottom), as
demonstrated with different AD-like disease murine models sensitized to
OVA (top middle). The underlying requirement for this pathway seems to
be chronic inflammation, which can also occur in other allergic
diseases. A continuous local inflammation may promote basophil tissue
infiltration, where they can reside in proximity to sensory neurons
favoring a basophil-neuronal interplay (right side). Bas, basophils.