Figure Legend
Figure 1 . Acute itch flares in AD patients are associated with increased levels of specific IgE (top left side). While chronic itch behavior is dependent on MC-neuronal communication, acute itch relies on basophil-neuronal interaction via the LTC4-CysLTR2 pathway (bottom), as demonstrated with different AD-like disease murine models sensitized to OVA (top middle). The underlying requirement for this pathway seems to be chronic inflammation, which can also occur in other allergic diseases. A continuous local inflammation may promote basophil tissue infiltration, where they can reside in proximity to sensory neurons favoring a basophil-neuronal interplay (right side). Bas, basophils.