Figure 1: Colocalization plots depicting the association of
single nucleotide polymorphisms (SNPs) with cortical ACE gene
expression, systolic blood pressure and Alzheimer’s disease (AD) risk.
The X axis shows position within the genome (build Hg19) and Y axis
denotes the -log10(p-value) for the association. Colour
denotes the linkage disequilibrium (LD) between different variants (see
legend). The results support that rs4291 is the most likely candidate
SNP underlying all these traits, therefore, representing a common causal
SNP for these traits.