Genetic colocalization
Colocalization analysis provided evidence for a shared causal variant for each pairwise combination (PP for colocalization of corticalACE gene expression and AD liability = 0.98; PP for colocalization of cortical ACE expression and SBP = 0.97; PP for SBP and AD liability = 0.98). In three-way colocalization by HyPrColoc, the estimated PP of full colocalization = 0.83. The variant rs4291 was the most likely shared causal variant for all traits (figure 1). Similar results were obtained when only considering AD cases and not also AD-by-proxy (Supplementary Results).