Genetic colocalization
Colocalization analysis provided evidence for a shared causal variant
for each pairwise combination (PP for colocalization of corticalACE gene expression and AD liability = 0.98; PP for
colocalization of cortical ACE expression and SBP = 0.97; PP for
SBP and AD liability = 0.98). In three-way colocalization by HyPrColoc,
the estimated PP of full colocalization = 0.83. The variant rs4291 was
the most likely shared causal variant for all traits (figure 1). Similar
results were obtained when only considering AD cases and not also
AD-by-proxy (Supplementary Results).