LIMITATION OF THE STUDY
This is prospective, but observational study and, even if most variables
are similar in both groups, it is not possible to reproduce the validity
of a randomized study. Moreover, most of bioprostheses used are
self-expandable, a well known risk factor for PPI, but their presence
constant in both groups. We think that the findings of this study can be
valid in general, as inflammation is a risk factor for the progression
of many valvular diseases.