Mechanism of Action
Sirolimus stimulates cytokines like IL-2 (interleukin-2), IL-4, IL-15
and inhibits proliferation and activation of T-lymphocytes. It binds to
FK binding protein 12 (FKBP12), immunophilin to generate an
immunosuppressive complex. It has no effect on calcineurin activity and
it inhibits the activation of a key regulatory kinase - mTOR (mammalian
target of rapamycin) [20].