Pharmaceutical Properties
The Immunosuppressant drug Sirolimus also known as Rapamune,is a
macrolide antiobiotic. The molecular formula of Sirolimus is
C51H79NO13. Physically,
it is off white in color in powdered form. It is soluble in solvents
such as acetone, acetonitrile, chloroform, benzyl alcohol, \soutetc.
and is also insoluble in water. The inactive ingredients in Rapamune
oral solution are ethanol, mono and diglycerides, ascorbyl palmitate,
propylene glycol, phosphatidylcholine etc. Some of the inactive
ingredients for Rapamune tablets are microcrystalline cellulose and
include talc, titanium dioxide, lactose, sucrose, polyethylene glycol,
calcium sulphate, and magnesium stearate [20-21].