Pharmaceutical Properties
The Immunosuppressant drug Sirolimus also known as Rapamune,is a macrolide antiobiotic. The molecular formula of Sirolimus is C51H79NO13. Physically, it is off white in color in powdered form. It is soluble in solvents such as acetone, acetonitrile, chloroform, benzyl alcohol, \soutetc. and is also insoluble in water. The inactive ingredients in Rapamune oral solution are ethanol, mono and diglycerides, ascorbyl palmitate, propylene glycol, phosphatidylcholine etc. Some of the inactive ingredients for Rapamune tablets are microcrystalline cellulose and include talc, titanium dioxide, lactose, sucrose, polyethylene glycol, calcium sulphate, and magnesium stearate [20-21].