REFERENCES
  1. Blumchen K, Beder A, Beschorner J, Ahrens F, Gruebl A, Hamelmann E et al. Modified oral food challenge used with sensitization biomarkers provides more real‐life clinical thresholds for peanut allergy. J Allergy Clin Immunol. 2014;134:390–398.
  2. Turner PJ, Wainstein BK. Crossing the threshold: can outcome data from food challenges be used to predict risk of anaphylaxis in the community? Allergy. 2017;72:9-12.
  3. Niggemann B, Lange L, Finger A, Ziegert M, Müller V, Beyer K. Accurate oral food challenge requires a cumulative dose on a subsequent day. J Allergy Clin Immunol. 2012;130:261–263.
  4. Graham F, Caubet JC, Eigenmann PA. Can my child with IgE-mediated peanut allergy introduce foods labeled with ”may contain traces”? Pediatr Allergy Immunol. 2020;31:601-607.
  5. Dua S, Ruiz-Garcia M, Bond S, Durham SR, Kimber I, Mills C, Roberts G, Skypala I, Wason J, Ewan P, Boyle R, Clark A. Effect of sleep deprivation and exercise on reaction threshold in adults with peanut allergy: A randomized controlled study. J Allergy Clin Immunol. 2019;144:1584-1594.e2.
  6. Patel N, Adelman DC, Anagnostou K, Baumert JL, Blom WM, Campbell DE, et al. Using data from food challenges to inform management of consumers with food allergy: A systematic review with individual participant data meta-analysis. J Allergy Clin Immunol. 2021 Feb 9:S0091-6749(21)00172-X. doi: 10.1016/j.jaci.2021.01.025. Epub ahead of print.
FIGURE LEGENDS
Figure 1 Challenge protocol used for “abbreviated” food challenges
Figure 2. Change in cumulative eliciting dose (cumED) at DBPCFC. Panel A : cumED at baseline DBPCFC (using standard incremental protocol) compared to abbreviated protocol. Red bar represents median, whiskers the interquartile range. Panel B : log-change in cumED when the abbreviated DBPCFC was undertaken with peanut butter in contrast to DBPCFC (either abbreviated protocol or standard protocol) with the water-continuous dessert matrix. ns, not significant.