Data collection
Patient data, including demographics, medical history, clinical
manifestations, laboratory examinations, comorbidities, complications,
and hospital stay were collected from the electronic medical records by
a trained team of physicians. All the data were independently reviewed.
Acute respiratory distress syndrome was defined according to the Berlin
Definition 12. Acute myocardial injury was defined as
blood level of cardiac biomarker cTnI increased above the
99th percentile upper reference limit13. Acute liver injury was defined as liver enzymes
and/or bilirubin were more than twice the upper reference limit13. Acute kidney injury was identified according to
the Kidney Disease: Improving Global Outcomes definition14. Coagulopathy was defined as a 3-s extension of
prothrombin time or a 5-s extension of activated partial thromboplastin
time 13.
Electrocardiogram
(ECG) monitoring
A 12-lead ECG monitoring was continuously performed for 2 hours using a
Holter monitor (CT-86, Baihui, Hangzhou City, China) in all enrolled
participants. All patients lied on the bed quietly with no drink or food
since 15 minutes before the monitoring until completion of the
monitoring. Holter software was used to analyze the heart rate and
arrhythmias. Sinus tachycardia was defined as an increase in sinus
rhythm to >100 beats/min. Atrial tachycardia was defined as
3 or more consecutive atrial premature contraction. All ECG data were
manually examined by
two
unsuspecting observers and
arbitrated
by electrophysiologists for any suspicious event classification.