Figure Legends
Figure 1. A) The effect of AIP on the specific and volumetric
productivity of aIL-1β-producing CHO cells in a batch culture compared
to control cultures containing no added peptide. Error bars indicate the
standard deviation for two technical replicate cultures in one
experiment, assuming that the data is normally distributed. These data
are from one representative run out of three exhibiting the same trend.
B) The effect of a negative control peptide (NCP) on the specific and
volumetric productivity in CHO-aIL-1β cells batch culture with 3 µM and
4 µM NCP added to the basal cell culture medium on day 0.
Figure 2. The effect of autophagy on the A) growth profiles and
B) viability for aIL-1β-producing CHO cells in batch cultures over time.
Cultures with no added peptide (Control) or with the negative control
peptide (NCP 3 µM) were experimental controls. The AIP concentrations
tested were 1 µM, 2 µM, 3 µM, and 4 µM. Error bars indicate the standard
deviation for two technical replicate cultures within one run, assuming
that the data is normally distributed. These data are from one
representative run out of three exhibiting the same trend.
Figure 3. The effect of
AIP (1-4 µΜ) on the specific and volumetric productivity of
aIL-1β-producing CHO cells in fed-batch cultures compared to the control
cultures containing no additional peptide. Error bars indicate the
standard deviation for two technical replicate cultures within one run,
assuming that the data is normally distributed. These data are from one
representative run out of three exhibiting the same trend.