Figure Legends
Figure 1. A) The effect of AIP on the specific and volumetric productivity of aIL-1β-producing CHO cells in a batch culture compared to control cultures containing no added peptide. Error bars indicate the standard deviation for two technical replicate cultures in one experiment, assuming that the data is normally distributed. These data are from one representative run out of three exhibiting the same trend. B) The effect of a negative control peptide (NCP) on the specific and volumetric productivity in CHO-aIL-1β cells batch culture with 3 µM and 4 µM NCP added to the basal cell culture medium on day 0.
Figure 2. The effect of autophagy on the A) growth profiles and B) viability for aIL-1β-producing CHO cells in batch cultures over time. Cultures with no added peptide (Control) or with the negative control peptide (NCP 3 µM) were experimental controls. The AIP concentrations tested were 1 µM, 2 µM, 3 µM, and 4 µM. Error bars indicate the standard deviation for two technical replicate cultures within one run, assuming that the data is normally distributed. These data are from one representative run out of three exhibiting the same trend.
Figure 3. The effect of AIP (1-4 µΜ) on the specific and volumetric productivity of aIL-1β-producing CHO cells in fed-batch cultures compared to the control cultures containing no additional peptide. Error bars indicate the standard deviation for two technical replicate cultures within one run, assuming that the data is normally distributed. These data are from one representative run out of three exhibiting the same trend.