Conclusion
Overall, this study provides strong support for modulating cellular
autophagy to increase monoclonal antibody production in the CHO cell
culture system, both in batch and fed-batch cultures. Despite the
negative impacts on cell growth and viability (that could be reduced),
the positive impacts on both cell specific and volumetric antibody
production were substantial. This unique peptide and its capacity to
specifically activate the autophagy cascade, merits further
consideration as a media additive for bioprocess refinement, and is thus
of particular relevance to industrial biotechnology.