Chloroquine and Hydroxychloroquine: how about switching?

Thiago Santana Novotny*^1,2, Mychelle Alves Monteiro¹, Patrícia Condé de Lima¹, Soraya Mendonça de Ochs¹, Fernando Antonio Simas Vaz², Flávia Ferreira de Carvalho Marques².

¹National Institute for Quality Control in Health, Oswaldo Cruz Foundation, 21040-900, Rio de Janeiro, RJ, Brazil.

²Department of Analytical Chemistry - Fundamental and Applied Analytical Chemistry Laboratory, Institute of Chemistry, Fluminense Federal University, 24020-141, Niterói, RJ, Brazil

Correspondence to : Thiago Santana Novotny, Instituto Nacional de Controle de Qualidade em Saúde (INCQS) – Fundação Oswaldo Cruz (Fiocruz), Avenida Brasil, 4365, 21040-900, Manguinhos, Rio de Janeiro - RJ - Brasil

thiago.novotny@gmail.com

FONE: +55(21)98797-2917

Abbreviations: CQ – Chloroquine, HCQ – Hydroxychloroquine, ADE – antibody dependent enhancement, WHO – World Health Organization, CoV – Coronaviruses, SARS – Severe Acute Respiratory Syndrome, MERS – Middle East Respiratory Syndrome, RAS – renin-angiotensin system.