2.1 Population
45 patients diagnosed COVID-19 infection were included in our study (National Health Commission: Seventh Edition Treatment plan for COVID-19) 8. Mild patients: the clinical symptoms are slight, and no pneumonia manifestations on imaging. Ordinary type: with fever, respiratory tract symptoms, etc. Imaging shows pneumonia. Severe patients: Adults with any of the following syndromes; 1. Short of breath, RR≥ 30 times/min; 2. Oxygen saturation ≤ 93% in rest condition; 3. Arterial blood oxygen partial pressure (PaO2) / oxygen concentration (FiO2) ≤300mmHg. Pulmonary imaging shows that the lesions progress significantly > 50% within 48 hours were treated as severe. Critical severity: 1. Respiratory failure occurs and mechanical ventilation is performed; 2. Shock occurs; 3. Combined organ failure requires intensive care.
Among the 45 patients, nine patients have preexisting cardiac disease (six patients with hypertension, one patient with coronary heart disease and hypertension , two patients has chronic heart failure and hypertension).The clinical history, laboratory data including high-sensitivity troponin T(hs-TnT), N-Terminal pro-brain natriuretic peptide (NT-pro BNP) and echocardiography data were collected at admission to the study(baseline). Because of the small study population, we divided the mild and ordinary type as mild group, 25 patients in total; severe and critical severity as severe group, 20 cases in total. The severe group in intensive care unit (ICU) were followed up for 16 days.7 severe patients recovered and were transferred out, only13 severe patients were still in intensive care unit and received the echocardiography at least twice(follow-up). Furthermore, 10 received echocardiography more than 7 times during hospital. The data collection was from February 22th to March 8th 2020. The first echocardiography in this study was performed on admission to the study, not at hospital admission.
23 normal people were included based on normal echocardiography and blood test during the March 2020 in west china hospital.