Lay summary
Intrahepatic cholestasis includes primary biliary cholangitis and
primary sclerosing cholangitis. It can cause fibrosis, cirrhosis and
eventually liver failure. Effective drugs for PBC and PSC are still
limited and new treatment strategies are urgently needed. This study
defines tectorigenin, an isoflavone, have the potential to alleviate
cholestatic liver disease, which is achieved mainly by relieving liver
inflammation and promoting the secretion of bile in hepatocyte.