Acknowledgements
This study was supported by grants from The First Hospital, Jilin University, Changchun of China; International Science and Technology Cooperation Program of Jilin Provincial Science and Technology Development of China(No. 20150414011GH), Norman Bethune Cultivation Plan of Jilin University(No. 2015320), the National Natural Science Foundation(No.81471216, NO.81671186, No.81671177, No.31600820) as well as from the Swedish Research Council(2015-03005).