Figure 4. NF-κb activity in the spinal cord, EAE score and pathological differences between the EAE and NF-κb blocked groups. (a) Phosphorylated NF-κb level is lower in the blocked group than in the EAE group and the prevention group is statistically different from the EAE group. (b) Intravenous BAY-11-7082 injection every 3 days from day 2 after the immunization until the peak hour showed that the prevention group had a lower score at the peak phase; Intravenous BAY-11-7082 injection every 3 days from day 10 after the immunization until the peak hour showed that the score was lower in the BAY-11-7082-injected treatment group compared with the EAE group. (c) Inflammatory cell infiltration and structural damage in the spinal cord are more severe in controls than in the prevention and treatment groups.