Figure 5: Comparison of samples grouped by normal ALT (≤50 IU/L) and elevated ALT (>50 IU/L). (A) miR-122 concentration (fM) and (B) K18 (U/L). Patient samples (healthy volunteers n=28; active TB n=44; latent TB n=142; NTM infection n=39; HIV-TB coinfection n=241). Statistical analysis of the significance of the difference between the groups calculated with the Mann-Whitney t-test (miR-122 P<0.0001; K18 P<0.0001). ROC analysis of samples grouped by normal ALT (≤50 IU/L) and elevated ALT (>50 IU/L), (C) miR-122 and (D) K18. MiR-122 (ROC-AUC = 0.93, 95 % CI = 0.88-0.98, P<0.001). K18 (ROC-AUC = 0.80, 95% CI = 0.72-0.87, P<0.0001). (ROC) receiver operator characteristic; (AUC) area under the curve.