What this study adds:
- The baseline concentrations of microRNA-122 and cytokeratin-18 did not
substantially differ across UK and Ugandan populations on treatment
for TB and HIV.
- These biomarkers significantly correlated with alanine transaminase
activity (current liver injury marker) and were elevated with DILI.
- MicroRNA-122 and cytokeratin-18 have potential in this context-of-use
and should be taken forward into larger studies which could provide
data for formal qualification.