4. Conclusion
We present a valuable case of advanced non-Sq NSCLC, treated with pemetrexed which led to a CR and long-term survival without recurrence for six years so far, after discontinuing all the drug treatments. Pemetrexed has significant efficacy for some non-Sq NSCLC cases, as demonstrated in the current case. For the patients with advanced non-Sq NSCLC, pemetrexed administration should be carefully considered.