Patients and Methods
All patients followed in a SFCE center and diagnosed with a SARS-CoV-2 infection who had undergone anti-cancer treatment in the past 6 months ago were enrolled in the study. We also included all patients from SFCE centers who underwent a hematopoietic stem-cell transplantation (HSCT) for any reason and with immunosuppressive therapy either ongoing or interrupted less than 6 months prior. Since SFCE centers may provide care in children and adolescents as well as in young adults, there was no limit of age to enroll patients in the study.
Diagnosis criteria for SARS-CoV-2 infection were as follows: (1) biologically proven infection with positive polymerase chain reaction (PCR) or positive specific positive IgM SARS-CoV-2 serology, (2) clinical and radiological diagnosis with at least two (if any contact with a suspected or confirmed COVID-19 case) or three (if no notion of contact) clinical signs (comprising fever, cough, loss of smell, loss of taste, myalgia, chest pain, dyspnea, respiratory distress syndrome, rhinorrhea, diarrhea, headaches, asthenia and skin rash) and computed-tomography(CT)-scan signs (ground glass opacities, crazy-paving, linear condensations with a peripheral and/or bilateral distribution) compatible with SARS-CoV-2 infection. All patients and their families were informed of this study. The study was approved by the ethics committee of the coordinating center (N°04/2020/ROU). This study is registered in clinicaltrial.gov (NCT04433871).