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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a novel coronavirus, causes the outbreak of Coronavirus Disease 2019 (COVID-19) leading to approximately 1.86 million confirmed infected cases and over 702,642 deaths worldwide, as of Aug 6, 2020 1. The COVID-19 also yields severe nosocomial infection, with an astonishing amount of 230,000 infections globally in healthcare workers2. In China, to triage the potential infected cases and prevent nosocomial infection, whoever has symptoms including fever, cough, and shortness of breath, will be first sent to special fever clinics. Fever clinics were initially established for the combat of severe acute respiratory syndrome (SARS) outbreak in 20023. They are designed to provide prompt assessment, management, laboratory examination and decision-making for the potential infected cases, which serves as the crucial first-line of defense to control nosocomial infection 4. China has set up approximately 15,000 fever clinics so far 5. As of February 3, 2020, data from the National Health Commission of the People’s Republic of China showed that a total of 220,865 people had visited fever clinics across the Chinese mainland 6. Guided by the primary principle of ‘early assessment, early detection, and early isolation’, fever clinics played a significant role in triaging suspected cases and minimize the risk of nosocomial infection during the COVID-19 combat in China 4. However, fever clinics failed to function normally as expected; for instance, a total of 1,101 healthcare providers in Wuhan had been infected as of February 6, 2020 7. In this comment, we systematically evaluated the current limitations of fever clinics and provided several potential solutions, aiming to enhance and maximize the capability and capacity of fever clinics for acute infectious diseases. Main results were summarized in Figure 1 for an easy-to-use purpose.