Ghana Standard Treatment Guidelines 2010[96] |
“Warfarin, oral,
adults: 10 mg daily at 6pm for 2 days, then 5 mg daily” |
“regular
dose adjustment and monitoring of INR until target of 2.0 and 3.0 is
attained” |
Namibia Standard Treatment Guidelines 2011[97] |
“Warfarin: 5 to 10
mg orally; start at same time as heparin” |
“adjust dose according to
INR” |
Ethiopia Standard Treatment Guidelines for General Hospitals
2014[98] |
“Warfarin (starting simultaneously with heparin), 5 mg
orally, daily” |
“dose adjusted to achieve target INR of 2.0 to
3.0” |
Uganda Clinical Guidelines. National Guidelines for Management of Common
Conditions 2016[99] |
“… plus warfarin 5mg single dose given
in the evening, commencing on the same day as heparin” |
“Maintenance
dose 2.5 to 7.5 mg single dose daily, adjusted according to the INR 2 to
3” |
Kenya National Guidelines for Cardiovascular Diseases Management
2018[100] |
“Recommended starting dose: 5 mg orally once a day” |
“Typical maintenance dose: 2 to 10 mg orally once a day. Dosage must be
individualized according to the patient’s INR” |
Standard Treatment Guidelines and Essential Medicines List for South
Africa, Hospital Level, Adults 2019[101]
|
Day 1:
5 mg daily (2.5 mg daily for high sensitivity)
2 to 3 days after initiation:
5-7.5 mg/d if INR < 1.5;
2.5-5 mg/d if INR 1.5 to 1.9;
2.5 mg/d if INR 2.0 to 2.5;
hold warfarin if INR > 2.5
2 to 3 days after last INR check:
7.5-10 mg/d if INR < 1.5;
5-10 mg/d if INR 1.5 to 1.9;
2.5-5 mg/d if INR 2.0 to 3.0;
hold warfarin if INR > 3
|
Increase weekly dose by 10% if INR < 1.5;
increase weekly dose by 5% if INR 1.5 to 1.9;
no change to warfarin dose if INR 2.0 to 3.0;
decrease weekly dose by 5% if INR 3.1 to 4.0;
decrease weekly dose by 10% if INR 4.1 to 5.0;
decrease weekly dose by 20% if INR 5.1 to 9.0
|