Guideline Warfarin dose initiation guideline Warfarin dose adjustment guideline
Ghana Standard Treatment Guidelines 2010[96] “Warfarin, oral, adults: 10 mg daily at 6pm for 2 days, then 5 mg daily” “regular dose adjustment and monitoring of INR until target of 2.0 and 3.0 is attained”
Namibia Standard Treatment Guidelines 2011[97] “Warfarin: 5 to 10 mg orally; start at same time as heparin” “adjust dose according to INR”
Ethiopia Standard Treatment Guidelines for General Hospitals 2014[98] “Warfarin (starting simultaneously with heparin), 5 mg orally, daily” “dose adjusted to achieve target INR of 2.0 to 3.0”
Uganda Clinical Guidelines. National Guidelines for Management of Common Conditions 2016[99] “… plus warfarin 5mg single dose given in the evening, commencing on the same day as heparin” “Maintenance dose 2.5 to 7.5 mg single dose daily, adjusted according to the INR 2 to 3”
Kenya National Guidelines for Cardiovascular Diseases Management 2018[100] “Recommended starting dose: 5 mg orally once a day” “Typical maintenance dose: 2 to 10 mg orally once a day. Dosage must be individualized according to the patient’s INR”
Standard Treatment Guidelines and Essential Medicines List for South Africa, Hospital Level, Adults 2019[101]
Day 1: 5 mg daily (2.5 mg daily for high sensitivity) 2 to 3 days after initiation: 5-7.5 mg/d if INR < 1.5; 2.5-5 mg/d if INR 1.5 to 1.9; 2.5 mg/d if INR 2.0 to 2.5; hold warfarin if INR > 2.5 2 to 3 days after last INR check: 7.5-10 mg/d if INR < 1.5; 5-10 mg/d if INR 1.5 to 1.9; 2.5-5 mg/d if INR 2.0 to 3.0; hold warfarin if INR > 3 Increase weekly dose by 10% if INR < 1.5; increase weekly dose by 5% if INR 1.5 to 1.9; no change to warfarin dose if INR 2.0 to 3.0; decrease weekly dose by 5% if INR 3.1 to 4.0; decrease weekly dose by 10% if INR 4.1 to 5.0; decrease weekly dose by 20% if INR 5.1 to 9.0