Conclusion
Our study shows that oxidative stress potentially plays a pivotal role in VCK children. It may be responsible for VKC ocular inflammation, triggering an increase of systemic, as well as local, H2O2 levels that lead to serious complications. Hence the importance of prompt therapy with CsA, able to reduce H2O2 levels.
However, more studies should be carried out to clarify the H2O2 role in the immunopathogenesis of VKC diseases and the connection with its severity.
ACKNOWLEDGMENTS Not applicable.
CONFLICT OF INTEREST All the authors declare that there are no known conflicts of interest associated with this publication.
FINANCIAL SUPPORT All the authors declare that there was no financial support for this work that could have influenced its outcome.
AUTHOR CONTRIBUTION AMZ and GB contributed equally to this article. AMZ, GB, VL, MN, and GDC contributed to the acquisition of data. AMZ performed the statistical analysis of data. AMZ and GB contributed to the writing of the manuscript. All authors revised and approved the final version of the manuscript.