Conclusion
Our study shows that oxidative stress potentially plays a pivotal role
in VCK children. It may be responsible for VKC ocular inflammation,
triggering an increase of systemic, as well as local, H2O2 levels that
lead to serious complications. Hence the importance of prompt therapy
with CsA, able to reduce H2O2 levels.
However, more studies should be carried out to clarify the H2O2 role in
the immunopathogenesis of VKC diseases and the connection with its
severity.
ACKNOWLEDGMENTS Not applicable.
CONFLICT OF INTEREST All the authors declare that there are no
known conflicts of interest associated with this publication.
FINANCIAL SUPPORT All the authors declare that there was no
financial support for this work that could have influenced its outcome.
AUTHOR CONTRIBUTION AMZ and GB contributed equally to this
article. AMZ, GB, VL, MN, and GDC contributed to the acquisition of
data. AMZ performed the statistical analysis of data. AMZ and GB
contributed to the writing of the manuscript. All authors revised and
approved the final version of the manuscript.