TC and onset of atopic dermatitis: Subset II Study
Our Subset II Study examined the onset of atopic dermatitis in children during a median follow-up time of 1,750 days (Figure 2). Among 155 subjects with high TC, 21 (13.5%) had new onset atopic dermatitis; and among 863 subjects with normal TC, 48 (5.6%) had new onset atopic dermatitis. The results indicated a significantly increased probability of atopic dermatitis in the high TC group (Hazard Ratio [HR]: 2.47; 95% CI: 1.23, 5.06; P = 0.012). The results of sensitivity analysis, in which we used more stringent criteria to define high TC (Supplementary Figure E1) and less stringent criteria to define atopic dermatitis (Supplementary Figure E2) were consistent.