Correlation between levels of various complement components and
clinical and pathological parameters in patients with active AAV
In 59 patients with active AAV, C5a levels had significant positive
correlations with C3a (r=0.371, p=0.004), MAC (r=0.355, p=0.006), and
factor B (r=0.281, p=0.031). However, there was no correlation between
various complement components and BVAS, daily proteinuria, serum
creatinine, C-reactive protein or erythrocyte sedimentation rate (ESR)
(Supplementary table S9).
In 13 patients with kidney biopsies, factor B level correlated with C3
deposition in the glomeruli (r=0.648, p=0.023), whereas all other
correlations between complement components and histological parameters
did not reach statistical significance (Supplementary table S10).