Correlation between levels of various complement components and clinical and pathological parameters in patients with active AAV
In 59 patients with active AAV, C5a levels had significant positive correlations with C3a (r=0.371, p=0.004), MAC (r=0.355, p=0.006), and factor B (r=0.281, p=0.031). However, there was no correlation between various complement components and BVAS, daily proteinuria, serum creatinine, C-reactive protein or erythrocyte sedimentation rate (ESR) (Supplementary table S9).
In 13 patients with kidney biopsies, factor B level correlated with C3 deposition in the glomeruli (r=0.648, p=0.023), whereas all other correlations between complement components and histological parameters did not reach statistical significance (Supplementary table S10).