The difference in morbidity and mortality between adult and pediatric
COVID-19 infections is dramatic. Understanding pediatric-specific acute
and delayed immune responses to SARS-CoV-2 is critical for the
development of vaccination strategies, immune-targeted therapies, and
treatment and prevention of MIS-C. The goal of this review is to
highlight research developments in understanding of the immune responses
to SARS-CoV-2 infections, with a specific focus on age-related immune
responses.