miR-21 |
Induced by Th2 cytokines in DC and macrophages and
promotes type 2- driven inflammation. |
IL-12p35 |
125-128 |
miR-126 |
Induced in airway wall and promotes type 2
inflammation. |
TOM1 |
123,124 |
let-7a-e |
Downregulated in CD4+ T cells and suppresses type 2
inflammation. |
IL-13 |
135 |
miR- 145 |
Induced by allergen exposure and promotes type 2
inflammation. |
|
134 |
miR-155
|
Induced in ILC2 in type 2 inflamed airways and neutralization
ameliorates experimental asthma phenotype.
Involved in Th2 mediated airway inflammation.
|
S1pr1
PU.1(?)
|
41,117-120
|
miR-23~27 |
Type 2 cells lacking this
miR-cluster express elevated type 2 cytokines. |
Gene network regulating
IL-4 |
11,133 |
miR17-92 |
Mice deficient in this miR-cluster develop an
augmented experimental asthma phenotype. |
|
121
|
miR-19a |
Upregulated in asthmatic airways and promotes
experimental asthma. |
SOCS1/ A20 |
59 |
miR-19b |
Downregulated in asthmatic airways. Exogenous
delivery of miR-19b mimics ameliorate experimental asthma. |
TSLP |
122 |
miR network
miR-27b (up)
miR-206 (down)
miR-106b (down)
miR-203 (down)
miR-23b (up)
|
A miR-network is induced in lung resident type 2 cells and comprises a
combination of induced miRs-27b and -23b as well as silenced miR-206,
miR106b and miR-203. Antagonism of expression levels reduces type 2
cytokine expression.
|
Fine tuning of multiple pathways, that suppress inhibitory signals and
allow activation and survival of type 2 cells
|
155
|