miRNA Function or findings Targets# References
miR-15b, 126, -139,-142, -186,-191, -342, -374a, -409, -660, -942, -1290 Circulating miRNAs (blood) correlating to lung function parameters in children N.D. 56
miR-16, -30d, -296 Circulating miRNAs (blood) correlating to bronchial hyperresponsiveness N.D. 57
miR-146a, -206, -720 Circulating miRNAs (blood) used in combination as potential asthma prediction markers N.D. 58
miR-16, -125b, -133b, -206, -299 Plasma miRNAs able to distinguish asthmatics from healthy individuals or those with allergic rhinitis N.D 48
let-7a, miR-21, -133a, -155, -328, -1248 Decreased in exhaled breath condensates from asthmatic compared to healthy subjects N.D 68
miR-21 Dysregulated in circulation and lungs in allergic experimental murine models and human allergic asthmatics, N.D 9-11
miR-155 Downregulated in the lymphocytes of allergic asthmatics during pollen season N.D 172
miR-19a
Increased in airway T cells Reduction in smooth muscle cells leads to enhanced remodeling
PTEN, A20
57,59
miR-221 Decreased levels in epithelial and sputum was associated with eosinophilic airway inflammation in asthma N.D. 61
miR-185 Identified in circulating eosinophils as a distinguisher between healthy and asthmatic subjects. A potential predictor of asthma severity in blood sera. N.D. 62
miR-16 Negatively correlates to lung function parameters ADRB2 66
miR-223, -513a and -625 Downregulated in the blood of dust mite allergic asthmatics compared to healthy individuals CBL, PPARGC1B, ESR1 55
let-7a Abundant in the lungs and regulates IL-13 expression IL-13 69
miR-1248 Interacts with the 3’UTR to promote IL-5 expression IL-5 70
miR-15a Low levels in CD4+ T cells in pediatric asthma subject VEGF 71
miR-146a Downregulated in bronchial brushing samples of asthma patients, inhibits IL-8 and CXCL1 expression and neutrophil migration IRAK1 148