let-7 |
Major regulatory mechanism for modulation IL-13
secretion and thereby type-2 inflammation |
JAK1/STAT3 , IL-13,
SOCS4 |
50,
135;50,169 |
miR-206 |
Regulator of the VEGF pathway |
S100A7A |
48 |
|
|
VEGF |
|
miR-338-3p |
Inhibitor of Wnt/β-catenin signaling and
inducer of epithelial-mesenchymal transition |
WNT/ β
-Catentin |
48 |
miR-329 |
Unknown |
TGF-β1 |
48 |
miR-26a |
modulation of TGF-β-dependent signalling
pathways and repression of inflammatory responses by promoting
regulatory T cell responses or through NF-κB inhibition |
SMAD2, SMAD3 |
48 |
miR-7 |
Unknown |
CMKLR1 |
49 |
miR-498 |
Suppressing Th17 cell differentiation via
STAT3 |
STAT3 |
48,50 |
miR-187 |
Regulation of T cell response via CD276 |
CD276 |
49,50 |
miR-143 |
Regulates memory T cell differentiation |
TGF-β1 |
49,50 |
miR-886 |
Regulates TGF pathway via SMAD3 |
SMAD3, FoxO1 |
49,50 |
miR-224 |
Regulates TGF pathway via SMAD4 |
SMAD4 |
49,50 |
miR-155 |
Important role in host defense, modulates
IL-13 pathway in macrophages determining the M2 phenotype |
IL13Ra1 |
|
51,52,170,171 |
|
|
|
miR-205 |
Activation of ERK17 pathway |
MICAL2 |
50 |
miR-572 |
Regulates type-1 cytokine expression |
SOCS1 |
53 |
miR-1228 |
Regulates type 2 responses |
PPAR |
53 |
miR-483 |
Inhibition of TGFβ1 |
TGFβ1 |
53 |
miR-1908 |
Inhibition of TGFβ1 |
SMAD2,
SMAD3 |
|
MMP2 |
53 |
|
|
miR-126 |
Counter-regulation of IL4 effect |
VEGF, IRS1 |
53 |
miR-92a |
Regulation of IL4 effect |
WNT5a |
53 |
miR-125a |
Dampens down TLR pathway via IL10,
suppresses A20 |
TLR, A20 |
53 |
miR-19a |
Activates TGFβ signaling |
TGFβ1 |
53 |
miR-106a |
Regulation of authophagic activity |
NOD1/2 |
53 |
miR-181c |
Down-regulates Osteopontin, modulating TGF |
Osteopontin |
53 |
miR18a |
Regulating TGF pathway |
CTGF |
48 |