miRNA Function Target References
miR-21 Induced by Th2 cytokines in DC and macrophages and promotes type 2- driven inflammation. IL-12p35 125-128
miR-126 Induced in airway wall and promotes type 2 inflammation. TOM1 123,124
let-7a-e Downregulated in CD4+ T cells and suppresses type 2 inflammation. IL-13 135
miR- 145 Induced by allergen exposure and promotes type 2 inflammation. 134
miR-155
Induced in ILC2 in type 2 inflamed airways and neutralization ameliorates experimental asthma phenotype. Involved in Th2 mediated airway inflammation. S1pr1 PU.1(?)
41,117-120
miR-23~27 Type 2 cells lacking this miR-cluster express elevated type 2 cytokines. Gene network regulating IL-4 11,133
miR17-92 Mice deficient in this miR-cluster develop an augmented experimental asthma phenotype.  121
miR-19a Upregulated in asthmatic airways and promotes experimental asthma. SOCS1/ A20 59
miR-19b Downregulated in asthmatic airways. Exogenous delivery of miR-19b mimics ameliorate experimental asthma. TSLP 122
miR network miR-27b (up) miR-206 (down) miR-106b (down) miR-203 (down) miR-23b (up)
A miR-network is induced in lung resident type 2 cells and comprises a combination of induced miRs-27b and -23b as well as silenced miR-206, miR106b and miR-203. Antagonism of expression levels reduces type 2 cytokine expression.
Fine tuning of multiple pathways, that suppress inhibitory signals and allow activation and survival of type 2 cells
155