Human data |
|
|
miR-183
miR-324
miR-132
|
In controlled exposures in atopic subjects (exposure chamber) , the
miRNA expression was modulated by allergen exposure, but not
additionally by diesel exposure
|
92
|
miR-21 (up)
miR-30e (up)
miR-215 (up)
miR-144 (up)
|
In controlled exposures in asthma patients (exposure chamber), diesel
exposure was associated with increased expression of miR-21, miR-30e,
miR-215 and miR-144.
miR-144 and miR-21 associated with systemic oxidative stress markers and
negative correlation between miR-144 and antioxidant genes
|
93
|
miR-199a1 (down) |
miR-199a controls AXL (receptor kinase of the TAM
(TYRO3, AXL, MERTK) family. Maternal smoking is associated with
increased methylation of AXL and with reduced expression of miR-199a.
Combination of material smoking and increased AXL methylation alters the
risk of childhood bronchitis symptoms. |
95. |
miR-223 (up) |
Prenatal tobacco exposure is associated with high miR-223
expression in cord and maternal blood with low Treg numbers |
96 |
Murine data |
|
|
miR-221 (up)
miR-16 (up)
miR-130 (down)
|
In a model cigarette-aggravated allergic asthma (in utero side stream
cigarette smoke, followed by Aspergillus fumigatus exposure), the
altered miRNAs are associated with apoptosis and anti-angiogenesis
pathways
|
98
|
miR-155 (up)
miR-21 (up)
miR-18 (up)
|
In a model cigarette-aggravated allergic asthma (in utero side stream
cigarette smoke, followed by Aspergillus fumigatus exposure),
these miRNAs are positively associated with Type2 cytokines in
bronchoalveolar lavage fluid
|
99
|