Treatment failure
A total of 33 studies enrolling 3994 neonates with 678 events in the
network were analysed (Figure 2, Table 2). Both NIPPV and BiPAP
were associated with lesser risk of treatment failure when compared to
HFNC [0.42 (0.30, 0.63) and 0.53 (0.35, 0.81), respectively] and
CPAP [0.56 (0.44, 0.71) and 0.69 (0.51, 0.93) respectively]
(Figure 3, Table 3) . The SUCRA for NIPPV, BiPAP, CPAP and HFNC
were 0.96, 0.70, 0.32 and 0.01 respectively. (Figure 4) .
Meta-regression showed a trend similar to the outcome of mechanical
ventilation. (E-Figure 6) .