Montage of axial slices overlaid on the average gray matter image of all study subjects.
All local maxima pFWE < 0.001, all clusters pFWE < 0.001. Color bar indicates F-values, numbers indicate MNI coordinates in the z-direction.
We here show for the first time a differential brain response to histamine provocation in HDM AR patients versus HCs, in regions involved in interoception (i.e. monitoring and perceiving the physiological state of the body). These observations are of utmost importance to understand the psycho-emotional impact of chronic allergic inflammation and warrant further studies.