Montage of axial slices overlaid on the average gray matter image of all
study subjects.
All local maxima pFWE < 0.001, all clusters
pFWE < 0.001. Color bar indicates F-values,
numbers indicate MNI coordinates in the z-direction.
We here show for the first time a differential brain response to
histamine provocation in HDM AR patients versus HCs, in regions involved
in interoception (i.e. monitoring and perceiving the physiological state
of the body). These observations are of utmost importance to understand
the psycho-emotional impact of chronic allergic inflammation and warrant
further studies.