7-3. Management
Data regarding PPI induced delayed HSRs and the role of diagnostic tests
in these types of reactions are limited. Cross-reactivities have been
reported in non-immediate HSRs to PPIs as seen in immediate
reactions.47,71 DPT with the culprit drugs in patients
with severe delayed HSRs may cause fatal recurrence of the reactions and
it is not recommended. In patients who mandatory required PPI, the
choice of an alternative PPI may be based on LAT and/or patch test
results and tolerance should be tested by DPT.47,71