7-3. Management
Data regarding PPI induced delayed HSRs and the role of diagnostic tests in these types of reactions are limited. Cross-reactivities have been reported in non-immediate HSRs to PPIs as seen in immediate reactions.47,71 DPT with the culprit drugs in patients with severe delayed HSRs may cause fatal recurrence of the reactions and it is not recommended. In patients who mandatory required PPI, the choice of an alternative PPI may be based on LAT and/or patch test results and tolerance should be tested by DPT.47,71