7-1. Clinical features
All clinical features of delayed HSRs have been reported with
PPI.27 They can induce mild maculopapular eruption
(MPE)71,72, fixed drug eruption
(FDE)71,73 but also severe generalized bullous FDE
(GBFDE)71, photosensitization with rabeprazole and
esomeprazole,74 symmetrical drug-induced flexural
exanthema (SDRIFE)47, DRESS71,75,76,
acute generalized exanthematous pustulosis71,77,78 and
TEN.71,79,80,81,82