7-2. c. Provocation tests in non-immediate hypersensitivity to PPIs
The value of DPT with PPIs for delayed T cell-mediated reactions is unknown. Delayed T cell-mediated reactions after PPI intake are rare. For delayed reactions to PPI, the clinical history together with patch testing is generally considered sufficient to detect PPI delayed hypersensitivity.28 We do not know of any study evaluating the role of the DPT in PPI delayed hypersensitivity. However, we do recommend DPT in case of a doubtful history and negative skin test results in non-severe delayed reactions in order to exclude PPI hypersensitivity as a 100% sensitivity cannot be assumed.