4-CLASSIFICATION
HSRs to PPIs may be immediate or non-immediate/delayed and vary from
mild symptoms to life-threatening disorders, including urticaria,
angioedema and anaphylaxis, maculopapular eruption, contact dermatitis
(occupational), photoallergic dermatitis, erythroderma, drug reaction
with eosinophilia and systemic symptoms (DRESS) syndrome,
Stevens-Johnson syndrome/Toxic epidermal necrolysis
(SJS/TEN).27 Most reported reactions to PPIs are
immediate HSRs3 and among them more than half are
anaphylaxis.2,17-19,23,28 Most HSRs to PPIs occur in
female (61%) and almost all cases are described in adults with a mean
age of 46±13 years.29 One case report described
anaphylaxis secondary to omeprazole in a 14-year-old
boy30 and another anaphylaxis to omeprazole and
pantoprazole in a 16-years old girl is also
described.31