(Figure 2E)
Four studies for sIgE-walnut [39, 45, 69, 156, 174] met inclusion
criteria for meta-analyses showing a pooled sensitivity of 87% and 82%
specificity. For Jug r 1 sensitivity has higher at 90% for a median
cut-off 0.2 kUA/L[45, 66, 69] (Figure
2F). Four studies for sIgE-almond [89, 148, 156, 174] met inclusion
criteria for meta-analyses, with a pooled sensitivity of 72% and 95%
specificity at a median cut of 3.4 kUA/L. Hazelnut and
walnut studies were heterogeneous regarding co-sensitizations,
comorbidities, and age of subjects. Studies for cashew and almond were
less heterogeneous than those for hazelnut and walnut.
For hazelnut, the maximum sensitivity was ≥ 90% using hazelnut-sIgE.
The maximum specificity was ≥ 90% for hazelnut SPT and Cor a 14-sIgE.
For cashew, maximum sensitivity was ≥ 90% and maximum specificity was ≥
90% for SPT to cashew, sIgE to cashew and Ana o 3-sIgE. For
walnut-sIgE, maximum specificity was ≥ 90% for Jug r 1. For almond,
maximum sensitivity and specificity were ≥ 90% for almond-sIgE
(Tables S5 and S6 ).