What question did this study address?
The manuscript describes the pharmacokinetics of tizoxanide, the active metabolite of nitazoxanide using a physiologically based pharmacokinetic (PBPK) model. The validated PBPK model was used to estimate the optimal doses required for SARS-CoV-2 treatment or prevention such that >90% of the simulated population would have tizoxanide concentrations in the plasma and lung above the reported 90% effective concentration (EC90) value of nitazoxanide for the entire dosing interval.