k. ■ FIGURE
LEGENDS
Figure 1:
Scatter plot showing the relationship between propofol elimination
clearance after three-compartment base model fit. (A) gestational age
(GA, weeks), (B) postnatal age (PNA, weeks), (C) postmenstrual age (PMA,
weeks) and (D) body weight (BW, kg).
Figure 2:
Goodness of fit plots; (left) observed vs population predicted
concentrations, (right) observed vs individually predicted
concentrations. Black full lines represent the line of unity; red full
line is a loess smooth. Grey dots represent the empirically Bayesian
estimates (EBEs);
Figure 3:
Visual predictive check (VPC) plots with visualized 90% prediction
intervals (red and blue areas) of the 10th,
50th and 90th percentiles for the
Allegaert study8 (left), the
Sepúlveda12 study (middle) and the Smits
study13 (right). Full lines represent the empirical
percentiles. Grey dots represent the observed data.