Objective function value Objective function value Objective function value
Model Covariates -2LL AIC BIC
Three-compartment base model None 589.44 615.44 650.19
Allometric fixed BW on all parameters 159.97 185.97 220.72
Emax-type model BW on all parameters, PMA on CL -42.40 -10.40 32.36
Richards model BW on all parameters, PMA on CL -48.92 -12.92 35.19
Emax -type model + birth term BW on all parameters, PMA and PNA on CL -50.17 -16.17 29.27
Richards model + birth term BW on all parameters, PMA and PNA on CL -57.88 -21.88 26.23
GA-PNA maturation model11-2LL, minus two times log likelihood; AIC, Akaike information criterion; BIC, Bayesian-Schwartz information criterion; BW, body weight; PMA, postmenstrual age; PNA, postnatal age; GA, gestational age; CL, elimination clearance; V1, volume of the central compartment BW on all parameters, GA and PNA on CL -66.17 -34.17 8.59
Final model BW on all parameters, GA and PNA on CL, PNA on V1 -81.51 -47.51 -2.07