Model |
Covariates |
-2LL |
AIC |
BIC |
Three-compartment base model |
None |
589.44 |
615.44 |
650.19 |
Allometric fixed |
BW on all parameters |
159.97 |
185.97 |
220.72 |
Emax-type model |
BW on all parameters, PMA on CL |
-42.40 |
-10.40 |
32.36 |
Richards model |
BW on all parameters, PMA on CL |
-48.92 |
-12.92 |
35.19 |
Emax -type model + birth term |
BW on all parameters, PMA and PNA on CL |
-50.17 |
-16.17 |
29.27 |
Richards model + birth term |
BW on all parameters, PMA and PNA on CL |
-57.88 |
-21.88 |
26.23 |
GA-PNA maturation model11-2LL, minus two times log likelihood;
AIC, Akaike information criterion; BIC, Bayesian-Schwartz information
criterion; BW, body weight; PMA, postmenstrual age; PNA, postnatal
age; GA, gestational age; CL, elimination clearance; V1, volume of the
central compartment |
BW on all parameters, GA and PNA on CL |
-66.17 |
-34.17 |
8.59 |
Final model |
BW on all parameters, GA and PNA on CL, PNA on V1 |
-81.51 |
-47.51 |
-2.07 |