a. i. Population pharmacokinetics of propofol in neonates and infants: gestational and postnatal age to determine clearance maturation
ii. Louis Sandra1, Anne Smits3,4, Karel Allegaert3,5, Johan Nicolaï6, Pieter Annaert1 and Thomas Bouillon1,2
1: Drug Delivery and Disposition, KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.
2: Senior Pharmacometrician, BioNotus, Niel, Belgium.
3: KU Leuven Department of Development and Regeneration, Leuven, Belgium.
4: Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.
5: Division of Clinical Pharmacy, Erasmus Medical Center, Rotterdam, the Netherlands
6: Development Science, UCB BioPharma SPRL, Braine-l’Alleud, Belgium
i. corresponding author: Louis Sandra, lsandra3@its.jnj.com
i. The authors confirm that the Principal Investigators for this paper are Anne Smits and Karel Allegaert and that they had direct clinical responsibility for patients.