b. STATEMENT 1: What is already known
about this
subject?
- Propofol is frequently used for induction of anesthesia and procedural
sedation in (pre)term neonates and infants, despite being off label in
this population.
- Being a UGT1A9 and CYP3A4/2B6 substrate, maturational on top of
morphometric effects have to be accounted for to describe the
pharmacokinetics in this population.
- Former propofol pharmacokinetic analyses account for elimination
clearance maturation using a PMA-dependent Emax-type maturation model.