VALUE STOCH. APPROX. STOCH. APPROX.
SE RSE(%)
Fixed Effects Fixed Effects Fixed Effects Fixed Effects
CL70 (L min-1 70 kg-1) 1.64 0.0986 6.02
V1­70 (L 70 kg-1) 21 1.97 9.37
Q270 (L min-1 70 kg-1) 3.86 0.368 9.54
V270 (L 70 kg-1) 43 1.4 3.25
Q3­70 (L min-1 70 kg-1) 0.518 0.0342 6.6
V370 (L 70 kg-1) 270 24.2 8.96
\(\mathbf{M}_{\mathbf{\text{birth}}\mathbf{,38}}\) 0.244 0.0256 10.5
\(\mathbf{T}_{\frac{\mathbf{1}}{\mathbf{2}}}\) (weeks) 4.77 0.923 19.4
\(\mathbf{\alpha}\) 6.71 0.525 7.83
\(\mathbf{\beta}\) 0.77 0.118 15.3
Standard Deviation of the Random Effects Standard Deviation of the Random Effects Standard Deviation of the Random Effects Standard Deviation of the Random Effects
CL70 0.409 0.0356 8.7
V170 0.271 0.109 40.2
Q2­70 0.484 0.0792 16.4
V11CL70, clearance of a 70 kg adult; V170, volume of the central compartment of a 70 kg adult; Q270, intercompartmental clearance between the central compartment and the first peripheral compartment of a 70 kg adult; V270, volume of the first peripheral compartment of a 70 kg adult; Q370, intercompartmental clearance between the volume of the central compartment and the volume of the second peripheral compartment of a 70 kg adult; V370, volume of the second peripheral compartment of a 70 kg adult; \(M_{birth,38}\), proportion of completed maturation at birth for a 38 weeks gestational age neonate; \(T_{\frac{1}{2}}\), time to achieve 50% of postnatal clearance maturation in weeks; \(\alpha\), shape factor; \(\beta\), shape factor to scale a postnatal age-dependent change of body weight; b, proportional error model term; SE, standard error; RSE, relative standard error. Standard errors were calculated using stochastic approximation.270 0.191 0.0636 33.3
Q370 0.465 0.0514 11.1
V370 0.593 0.0729 12.3
Error Model Parameters Error Model Parameters Error Model Parameters Error Model Parameters
b 0.153 0.00545 3.56