Mouse experiment
Female C57BL/6 wild type (WT) mice and il17a-/-mice were treated with curdlan intranasally.24-26 In some experiment, WT mice were given anti-CXCL13 antibody or LTβR-Ig fusion protein intraperitoneally. Histology and RT-PCR study were performed as mentioned elsewhere.27 As previously described,28 lymphoid aggregates with a dense lymphocyte core and > 50 cells were defined as eLTs, and those with fewer cells and/or dispersed lymphocyte localization were defined as lymphocyte clusters. All mice were used following protocols approved by the Animal Care and Use Committee of Tongji Hospital. More information is provided in this article’s Online Supplement.