* P<0.05 and ** P<0.01 vs. mepolizumab (statistical
analysis assessed by Student’s t-test); data represent the mean±SEM of
n=5 bronchial tissue from different subjects. AHR: airway
hyperresponsiveness; C+: positive control, passively sensitized bronchi;
C-: negative control, non-sensitized bronchi; ECn:
concentration inducing n% Emax; Emax:
maximal effect; IC50: concentration inducing 50%
inhibition AHR to histamine in passively sensitized bronchi;
pIC50: -logIC50.