# P<0.05 and ### P<0.001 vs. C- (statistical
analysis assessed by Student’s t-test); *P<0.05, **
P<0.01, and *** P<0.001 vs. C+ (statistical analysis
assessed by one-way ANOVA); data represent the mean±SEM of n=5 bronchial
tissue from different subjects. C+: positive control, passively
sensitized bronchi; C-: negative control, non-sensitized bronchi; CRC:
concentration-response curve; EC50: concentration
inducing 50% Emax; Emax: maximal
effect; pEC50: -LogEC50.
Table 2. Efficacy and potency of benralizumab and mepolizumab
after overnight incubation on the AHR to different concentrations of
histamine (EC50-90) in passively sensitized bronchi. The
pharmacological analysis was performed by assessing Emaxas the difference in airway contractility between C+ and C- tissues.