Legend to Figure 2
Figure (2): Proposed mechanisms of delayed drug hypersensitivity. This
data supports the role of reactive metabolites in the pathogenesis of
SSLR to β-lactam antibiotics and the key role of the hapten hypothesis
starting with bioactivation of the drug to a reactive metabolite and
following immune processing resulting in a mis-directed immune response
producing delayed drug hypersensitivity manifested as a SSLR.