Acknowledgements:
Author contribution’ statement: AAE designed the study, analyze the data and wrote the manuscript. AMA Collect data and blood samples and performed the in vitro testing, BDM recruit patients and collected clinical data. EM recruit patients and healthy controls to the study and revised the manuscript. MJR contributed to the original design of the study, recruitment of patients and writing of the manuscript.
This research was funded by the GSK-CIHR Chair in Paediatric Clinical Pharmacology to MJR.