Acknowledgements:
Author contribution’ statement: AAE designed the study, analyze the data
and wrote the manuscript. AMA Collect data and blood samples and
performed the in vitro testing, BDM recruit patients and collected
clinical data. EM recruit patients and healthy controls to the study and
revised the manuscript. MJR contributed to the original design of the
study, recruitment of patients and writing of the manuscript.
This research was funded by the GSK-CIHR Chair in Paediatric Clinical
Pharmacology to MJR.